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Palmatine

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Identification
Molecular formula
C21H22NO4
CAS number
3486-67-7
IUPAC name
(6aR)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol
State
State

Palmatine generally exists as a crystalline solid at room temperature, characterized by its stability under standard conditions.

Melting point (Celsius)
266.00
Melting point (Kelvin)
539.15
Boiling point (Celsius)
570.00
Boiling point (Kelvin)
843.15
General information
Molecular weight
352.44g/mol
Molar mass
352.4370g/mol
Density
1.3500g/cm3
Appearence

Palmatine appears as a yellow crystalline powder. It is often used as a natural dye due to its vibrant color.

Comment on solubility

Solubility of (6aR)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol

The solubility of (6aR)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol is an intriguing aspect of its chemical properties. This compound, characterized by its complex structure, often exhibits variable solubility depending on several factors. Below are key points to consider regarding its solubility:

  • Nature of Solvents: This compound tends to be more soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and methanol. However, it shows limited solubility in polar solvents like water.
  • Temperature Influence: As with many organic compounds, elevating the temperature can enhance solubility, as increased kinetic energy helps overcome solute-solvent interactions. For instance, in a heated ethanol solution, the compound may dissolve more readily.
  • pH Sensitivity: The solubility could be affected by the pH of the solution, given the presence of functional groups that can ionize under certain conditions.
  • Concentration Effects: At higher concentrations, solubility may be limited, leading to precipitation, which is essential to consider in formulations or reactions involving this compound.

It's crucial to emphasize that solubility is not only a physical property but a vital factor that influences the compound's behavior in various environments and applications. Understanding the solubility helps in tailoring formulations and predicting interactions with other compounds.

This compound exemplifies how the complexity of organic molecules can lead to distinctive solubility characteristics, making it a subject of interest in both research and practical applications.

Interesting facts

Interesting Facts about (6aR)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol

This fascinating compound plays a significant role in the field of medicinal chemistry. Here are some engaging insights:

  • Complex Structure: The molecular architecture of this compound includes a unique fusion of a dibenzoquinoline framework, which is known for its dye and biological activity.
  • Potential Therapeutic Applications: Research indicates that derivatives of dibenzoquinoline structures exhibit a variety of biological activities, including antifungal, antibacterial, and anticancer properties.
  • Histone Deacetylase Inhibition: Some studies suggest compounds with similar structures can serve as histone deacetylase inhibitors, thus playing a role in cancer therapy and epigenetic studies.
  • Natural Occurrence: Components similar to this compound were initially sourced from natural products, illustrating the connection between synthetic and naturally occurring compounds in pharmaceutical research.
  • Reaction Chemistry: The compound's synthesis often involves complex reaction pathways that challenge chemists to explore innovative synthetic methodologies.

As we delve deeper into the characteristics and functionalities of (6aR)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol, we continuously uncover its potential, making it a thrilling subject of study for both seasoned scientists and students alike.

Synonyms
Apocodeine
641-36-1
Apocodeine HCl
APOCIDEINE
OBF8X37Y5W
CHEMBL154709
Apocodein
(6aR)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol
4H-Dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-10-methoxy-6-methyl-, (R)-(CI)
R-(-)-Apocodeine (1.0mg/ml in Acetonitrile)
UNII-OBF8X37Y5W
BRN 0032938
(6AR)-10-METHOXY-6-METHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO(DE,G)QUINOLIN-11-OL
6a.beta.-Aporphin-11-ol, 10-methoxy-
APOCODEINE [MI]
(-)-APOCODEINE
6a-beta-APORPHIN-11-OL, 10-METHOXY-
Lopac0_000425
5-21-05-00334 (Beilstein Handbook Reference)
(-)-(R)-APOCODEINE
SCHEMBL1349371
DZUOQMBJJSBONO-CQSZACIVSA-N
DTXSID901016508
BDBM50016019
NSC785152
CCG-204517
NSC-785152
SDCCGSBI-0050410.P002
4H-Dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-10-methoxy-6-methyl-, (R)-
NCGC00162151-02
NCGC00162151-04
Q27285553
APOMORPHINE HYDROCHLORIDE HEMIHYDRATE IMPURITY A [EP IMPURITY]
10-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol(apocideine)
4H-DIBENZO(DE,G)QUINOLIN-11-OL, 5,6,6A,7-TETRAHYDRO-10-METHOXY-6-METHYL-, (6AR)-