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Colchine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
(6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol
State
State

Colchicine is typically a solid at room temperature.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
732.00
Boiling point (Kelvin)
1 005.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4420g/mol
Density
1.2000g/cm3
Appearence

Colchicine typically appears as a pale yellow powder or as white to almost white crystalline powder. It is known for its needle-like crystal structure.

Comment on solubility

Solubility of (6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

The solubility of (6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol in various solvents presents interesting characteristics:

  • Polar Solvents: This compound tends to exhibit limited solubility in polar solvents due to its hydrophobic aromatic structure.
  • Non-polar Solvents: It may show better solubility in non-polar solvents, as the compound's large non-polar regions favor interactions with similar solvent characteristics.
  • Solvent Mixtures: The best solubility results might be obtained from mixtures of polar and non-polar solvents, as this can help to maximize interactions between the solvent and solute.

Key factors affecting solubility:

  • Molecular Structure: The complex molecular structure, with multiple rings and functional groups, influences how the compound interacts with solvents.
  • Temperature: Increasing the temperature often enhances solubility for many organic compounds, which may apply here as well.
  • pH Levels: The pH of the solution can affect solubility, particularly due to the presence of the hydroxyl group, which may engage in protonation or deprotonation depending on the environment.

In conclusion, while (6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol may show variable solubility in different solvents, understanding its structure and the nature of potential solvents is crucial for predicting and optimizing its dissolving behavior.

Interesting facts

Interesting Facts about (6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol

(6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol is a fascinating chemical compound that has drawn the interest of scientists due to its unique structure and potential applications. Here are some key points worth noting:

  • Structural Complexity: This compound features a complex fused ring system, characteristic of the dibenzoquinoline family, which contributes to its intriguing chemical properties.
  • Biological Activity: Compounds with similar structures have been investigated for their bioactive properties, suggesting that this specific compound could possess interesting pharmacological effects.
  • Synthetic Pathways: The synthesis of (6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol may involve advanced organic synthesis techniques that highlight the creativity and innovation within synthetic chemistry.
  • Research Potential: Due to its unique features, this compound may be a candidate for research in fields such as medicinal chemistry, materials science, and possibly even in the development of novel therapeutic agents.

In summary, (6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol is more than just a chemical formula; it represents an opportunity for scientific exploration and discovery. As stated by one renowned chemist, "The beauty of chemistry lies in its ability to transform the ordinary into the extraordinary." This compound is a perfect example of that sentiment!

Synonyms
(-)-Caaverine
6899-64-5
NORAPORPHIN-1-OL, 2-METHOXY-
2-Methoxynoraporphin-1-ol
(6aR)-2-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol
4H-Dibenzo(de,g)quinolin-1-ol, 5,6,6a,7-tetrahydro-2-methoxy-
C09368
CHEBI:84
DTXSID00219034
Q27105227