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Ajmalicine

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Identification
Molecular formula
C21H24N2O2
CAS number
483-04-5
IUPAC name
[(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanol
State
State

At room temperature, Ajmalicine is typically a solid.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
313.00
Boiling point (Kelvin)
586.15
General information
Molecular weight
352.46g/mol
Molar mass
352.4550g/mol
Density
1.1100g/cm3
Appearence

Ajmalicine appears as a yellow to brown amorphous powder or crystalline solid.

Comment on solubility

Solubility of [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanol

The solubility of a compound can greatly influence its usability in various applications, especially in pharmaceuticals and material science. For the compound [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanol, understanding its solubility profile is crucial.

Key Points to Consider:

  • Polarity: Solubility is often driven by the polarity of the molecule. Given the indole structure in this compound, we can anticipate a moderate level of polarity which may impact its solubility in various solvents.
  • Solvent Interaction: Generally, compounds with similar polar characteristics will dissolve better. Thus, this compound may have reasonable solubility in polar solvents such as water or alcohols, but may struggle in nonpolar environments.
  • Hydrogen Bonding: Possible hydrogen bonding with water molecules makes it likely to be more soluble in aqueous solutions, enhancing its interactions and accessibility in biological systems.
  • Hydrophobic Regions: The hydrophobic regions may limit solubility, especially in highly polar solvents. This duality can create a unique profile influencing its behavior in drug formulation.

In conclusion, while the specific numerical solubility data for [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanol might not be readily available, it is essential to perform solubility studies to better understand its applications. Further exploration of its solubility characteristics can yield helpful insights for its practical use.

Interesting facts

Exploring the Unique Compound: [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanol

This intriguing compound belongs to a class of molecules that have garnered significant interest in the fields of medicinal chemistry and pharmacology. Its complex structure, featuring a fused indole-quinoline system, imbues the compound with distinctive properties that can impact biological systems.

Key Features of the Compound

  • Structural Complexity: The unique arrangement of carbons and nitrogens allows for a variety of conformations, which can influence how the molecule interacts with biological targets.
  • Potential Biological Activity: Compounds similar to this one have shown promise as leads in drug design, particularly for neurodegenerative diseases and cancer therapies. They may exhibit antioxidant properties and can modulate neurotransmission.
  • Synthetic Routes: The intricate construction of this compound offers a rich ground for organic chemists, with various synthetic pathways providing unique challenges and opportunities for innovation in synthesis techniques.
  • Research Applications: Due to its potential pharmacological properties, ongoing research is essential. Understanding its mechanism of action can pave the way for novel therapeutic strategies.

As a chemistry student or scientist, one can appreciate the profound implications that studying such a compound can have on the advancement of medicinal chemistry. As we venture deeper into its synthesis and biological evaluation, we uncover the potential benefits and applications that could revolutionize treatments for various ailments. In the words of Nobel Laureate Elias James Corey, "The best way to predict the future is to invent it." With compounds like this, each step forward is a leap into the vast possibilities of modern science.

Synonyms
lysergol
602-85-7
NTR684Z1AZ
CHEBI:60528
[(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanol
1413-67-8
9,10-Didehydro-6-methyl-8-hydroxymethylergoline
UNII-NTR684Z1AZ
(6-methyl-9,10-didehydroergolin-8beta-yl)methanol
(7-Methyl-4,6,6a,7,8,9-hexahydro-indolo(4,3-fg)quinolin-9-yl)-methanol
(7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-yl)-methanol
EINECS 210-024-5
NSC 196867
[(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methanol
BRN 0088476
4-23-00-02717 (Beilstein Handbook Reference)
Ergoline, 9,10-didehydro-8-hydroxymethyl-6-methyl-
Ergoline-8.beta.-methanol, 9,10-didehydro-6-methyl-
Ergoline-8-methanol, 9,10-didehydro-6-methyl-, (8.beta.)-
9,10-didehydro-6-methylergoline-8b-methanol
((6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo(4,3-fg)quinolin-9-yl)methanol
((6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo(4,3-fg)quinoline-9-yl)methanol
(6-methyl-6,11-diazatetracyclo(7.6.1.02,7.012,16)hexadeca-1(16),2,9,12,14-pentaen-4-yl)methanol
{6-methyl-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),2,9,12,14-pentaen-4-yl}methanol
Ergoline-8beta-methanol, 9,10-didehydro-6-methyl-
Ergoline-8-methanol, 9,10-didehydro-6-methyl-, (8beta)-
(6-Methyl-9,10-didehydroergolin-8-yl)methanol-, (8.beta.)-
9,10-Didehydro-6-methyl-8-hydroxymethylergoline, (8.beta.)-
Ergoline-8-methanol, 9,10-didehydro-6-methyl-, (8-beta)-
Methanol, 1-((8beta)-9,10-didehydro-6-methylergolin-8-yl)-
9,10-Didehydro-6-methyl-8-hydroxymethylergoline, (8beta)-
Ergoline-8beta-methanol, 9,10-didehydro-6-methyl-(8CI)
(6-Methyl-9,10-didehydroergolin-8-yl)methanol-, (8beta)-
Ergoline-8-methanol, 9,10-didehydro-6-methyl-, (8-beta)-(9CI)
Ergoline-8-methanol, 9,10-didehydro-6-methyl-, (8beta)-(9CI)
bixjfijybljtmk-uhfffaoysa-n
indolo(4,3-fg)quinoline, ergoline-8-methanol deriv.
indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
Lysergole
CHEMBL39947
LOL
(8beta)-9,10-Didehydro-6-methylergoline-8-methanol; Ergoline-8beta-methanol, 9,10-didehydro-6-methyl- (8CI); Lysergol (6CI,7CI); Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.; NSC 196867
Prestwick_308
Prestwick0_000454
Prestwick1_000454
Prestwick2_000454
Prestwick3_000454
BSPBio_000528
GTPL123
cid_14987
MLS001049075
DivK1c_000515
SCHEMBL178071
SPBio_002467
BPBio1_000582
MEGxp0_001732
ACon0_000797
ACon1_000057
HMS501J17
KBio1_000515
((6aR,9R)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl)methanol
BIXJFIJYBLJTMK-MEBBXXQBSA-N
NINDS_000515
HMS1569K10
HMS2096K10
HMS2271M04
HY-N6809
TNP00316
BDBM50016479
MFCD00010029
AKOS030490884
FL31448
Phytochem 12: 2435 (1973)
IDI1_000515
SMP1_000185
NCGC00017367-01
AS-18087
SMR000386913
CS-0092658
NS00043437
E75857
A923435
SR-01000758923
Q6710130
SR-01000758923-3
BRD-K27871032-001-02-6
BRD-K27871032-001-04-2
((6aR)-7-Methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl)methanol