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Fluoromethyl tetrabenazine chloride

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Identification
Molecular formula
C19H20ClFN2
CAS number
1621709-58-5
IUPAC name
(6aS)-10-fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium;chloride
State
State

At room temperature, Fluoromethyl tetrabenazine chloride is in a solid state, which is common for many ionic compounds such as chlorides of complex organic structures.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
394.89g/mol
Molar mass
394.8910g/mol
Density
1.3200g/cm3
Appearence

Fluoromethyl tetrabenazine chloride typically appears as a white to off-white crystalline solid. Its appearance is characteristic of many organic chlorinated compounds.

Comment on solubility

Solubility of (6aS)-10-fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium;chloride

The solubility of the compound (6aS)-10-fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium;chloride can be influenced by various factors. Understanding the solubility characteristics is essential for its practical applications. Here are some key points regarding its solubility:

  • Solvent Effects: This compound exhibits variable solubility in different solvents. It is generally soluble in polar organic solvents like methanol and ethanol, while showing limited solubility in non-polar solvents.
  • Role of Ionic Nature: As a salt (chloride), the ionic nature significantly contributes to its solubility in aqueous solutions. The presence of the Cl⁻ ion allows for favorable interactions with water molecules.
  • Temperature Dependency: Like many organic salts, its solubility may increase with temperature, allowing for higher dissolution rates at elevated temperatures.
  • pH Influence: The solubility might also be affected by the pH of the solution, potentially altering the ionization state of the compound and thereby influencing its overall solubility profile.

In conclusion, while (6aS)-10-fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium;chloride is expected to have good solubility in some solvents, practical use would require thorough testing under varied conditions to determine its precise solubility characteristics.

Interesting facts

Interesting Facts about (6aS)-10-Fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium; Chloride

(6aS)-10-fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium; chloride is a fascinating compound with significant implications in the field of medicinal chemistry. Here are some intriguing points about this compound:

  • Complex Structure: This compound features a unique bicyclic structure that combines elements from both quinoline and dibenzocycloheptene systems. The presence of multiple fused rings contributes to its intricate chemical properties.
  • Fluorination: The introduction of a fluorine atom into organic molecules can dramatically enhance their biochemical behavior. In this compound, the fluorine atom potentially increases lipophilicity, influencing its interaction with biological targets.
  • Applications in Pharmaceuticals: Compounds similar to this one are often studied for their antimalarial and anticancer properties. Its structural similarity to known bioactive compounds makes it a candidate for drug development.
  • Stereochemistry: The specific stereochemistry at the 6a position, marked by the (6aS) configuration, is crucial to its pharmacological activity. Stereoisomers can exhibit vastly different biological properties.
  • Chloride Counterion: The inclusion of chloride as a counterion not only influences the solubility and stability of the molecule but also can play a role in its biological half-life and activity in vivo.

Overall, (6aS)-10-fluoro-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium; chloride embodies a rich intersection of structure and function, making it a compelling subject for ongoing research and exploration in the fields of organic and medicinal chemistry. Its potential applications could lead to significant advancements in therapeutic agents.

Synonyms
10-Fluoroaporphine hydrochloride
APORPHINE, 10-FLUORO-, HYDROCHLORIDE
4H-Dibenzo(de,g)quinoline, 10-fluoro-5,6,6a,7-tetrahydro-6-methyl-, hydrochloride
3833-87-2
4H-Dibenzo(de,g)quinoline, 10-fluoro-5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (9CI)