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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
(6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
State
State

At room temperature, colchicine is a solid.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
399.44g/mol
Molar mass
399.4370g/mol
Density
1.2200g/cm3
Appearence

Colchicine appears as a pale yellow powder or as pale yellow flakes and is a crystalline solid. It is slightly bitter and has no smell.

Comment on solubility

Solubility of (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

The solubility of (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline can be intricate due to its complex organic structure. When evaluating its solubility, several factors should be considered:

  • Polarity: The presence of methoxy groups may enhance solubility in polar solvents, while the overall hydrophobic character of the compound may limit its solubility in water.
  • Solvent Compatibility: This compound may show better solubility in organic solvents such as ethanol, methanol, or dichloromethane due to its nonpolar regions.
  • Temperature Influence: As with many organic compounds, an increase in temperature generally increases solubility, possibly allowing for greater dissolution in selected solvents.
  • Structure-Activity Relationship: The arrangement of the functional groups plays a critical role in its interaction with solvents, impacting the solubility profile.
  • Potential for Crystallinity: The compound may exhibit solid-state behavior that affects its dissolved state, potentially leading to variability in solubility based on purity and method of synthesis.

In summary, the solubility of (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline is likely conditional upon both its molecular structure and the choice of solvent. Factors such as polarity and temperature can significantly influence its behavior in solution. Thus, understanding the solubility characteristics of this compound is vital for its practical application in various fields.

Interesting facts

Interesting Facts About (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

(6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline is a fascinating compound that sits at the intersection of organic chemistry and medicinal research. Here are some key points to consider:

  • Structural Complexity: This compound features a unique fused ring structure that includes two benzene rings, contributing to its complex molecular behavior and properties.
  • Potential Biological Activity: Due to its intricate structure, compounds like this one are often investigated for potential pharmaceutical applications, including their effects on neurological and psychiatric conditions.
  • Importance of Stereochemistry: The (6aS) designation indicates a specific stereochemistry, which is crucial in determining the biological activity and interaction of the molecule with biological targets.
  • Historical Context: Compounds in the dibenzoquinoline class have been of interest since the early days of organic synthesis, often explored in the context of alkaloids and their derivatives.
  • Research Interests: Ongoing studies often focus on understanding the synthesis pathways to create derivatives of this compound that may enhance its activity or reduce potential side effects.

This compound exemplifies the beauty and intricacy of organic chemistry, showcasing how mathematic constructs can lead to real-world applications, particularly in therapeutic settings. As researchers continue to explore its properties and uses, (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline represents both a challenge and an exciting opportunity within the chemical sciences.

Synonyms
dl-Nuciferine
Aprphine, 1,2-dimethoxy-, (+-)-
(+-)-1,2-Dimethoxyaporphine
DTXSID80207378
5868-18-8
4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (+-)-
(6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline
(6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
DTXCID80129869
4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (+-)-(9CI)
CHEMBL4289859