Skip to main content

Galanthamine

ADVERTISEMENT
Identification
Molecular formula
C17H21NO3
CAS number
357-70-0
IUPAC name
(6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol
State
State

At room temperature, galanthamine is a solid compound.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
344.30
Boiling point (Kelvin)
617.45
General information
Molecular weight
287.34g/mol
Molar mass
287.3370g/mol
Density
1.2936g/cm3
Appearence

Galanthamine appears as an off-white crystalline powder. It is often encountered in its hydrobromide or hydrobromide hydrate forms in pharmaceutical applications.

Comment on solubility

Solubility of (6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol

The solubility of (6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol can be influenced by various factors, including its molecular structure, polarity, and the presence of functional groups. Here are certain aspects that illustrate its solubility characteristics:

  • Polarity: The presence of methoxy groups suggests that the compound has polar characteristics, which may enhance its solubility in polar solvents such as water and alcohols.
  • Hydrophobic/ Hydrophilic Balance: The hydrophobic alkyl groups can create challenges for solubility in highly polar solvents, indicating a balance in solubility depending on solvent properties.
  • Solvent Dependency: The solubility may vary widely in organic solvents. For instance, the compound might be more soluble in non-polar solvents compared to water.
  • Temperature Effects: Like many organic compounds, an increase in temperature might improve solubility in certain solvents by increasing molecular motion.

In summary, the solubility of (6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol is likely to be influenced by its specific structural attributes and the choice of solvent. Understanding these aspects may enhance its practical applications in various chemical processes.

Interesting facts

Interesting Facts about (6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol

This fascinating compound, with its intricate structure, belongs to a class of organic compounds known as alkaloids, which are renowned for their diverse biological activities. Here are some noteworthy points about this intriguing molecule:

  • Natural Origins: Many alkaloids are derived from plants, where they often play essential roles in defense against herbivores and pathogens. This compound may find its sources in the rich flora of specific regions.
  • Biological Significance: Alkaloids are often associated with pharmacological effects. Researchers are continually exploring compounds like this one for potential applications in medicine, particularly in areas such as neurology and oncology.
  • Structural Complexity: The presence of multiple methoxy groups in its structure suggests interesting steric and electronic effects that can influence its reactivity and interaction with biological systems.
  • Synthesis Challenges: The synthesis of such complex alkaloids often presents significant challenges, requiring advanced techniques in organic chemistry to navigate multiple reaction pathways and stereochemistry.
  • Research Frontiers: As scientists probe deeper into the properties of compounds like this one, they may uncover novel mechanisms of action, leading to discoveries in drug development, particularly for conditions that currently lack effective treatments.

In summary, the exploration of (6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol is not just an academic exercise but a gateway into the profound world of alkaloids and their potential impact on human health. As you dive deeper into the study of organic compounds, remember that each structure tells a story waiting to be told.

Synonyms
Isocorydine
Artabotrin
Luteanin
Uzokoridin
d-Isocorydine
L-(+)-Isocorydine
S-(+)-Isocorydine
Luteanine
Lindcarpine, N,O-dimethyl-
Aporphin-11-ol, 1,2,10-trimethoxy-
Luteanine (aporphine)
(+)-(S)-Isocorydine
(S)-(+)-Isocorydine
UNII-3B5E87JEOX
3B5E87JEOX
NSC 32979
NSC 645316
BRN 0094792
ISOCORYDINE, (+)-
4H-Dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (S)-
6aalpha-Aporphin-11-ol, 1,2,10-trimethoxy-
5-21-06-00132 (Beilstein Handbook Reference)
NSC-32979
6a-alpha-APORPHIN-11-OL, 1,2,10-TRIMETHOXY-
NSC-645316
4H-DIBENZO(DE,G)QUINOLIN-11-OL, 5,6,6A,7-TETRAHYDRO-1,2,10-TRIMETHOXY-6-METHYL-, (6AS)-
4H-Dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (+-)
475-67-2
(+)-isocorynoline
(+)-Isocorydine
Artabotrine
Isocorydine (+)
S-ISOCORYDINE (+)
(S)-isocorydine
4H-Dibenzo[de,g]quinolin-11-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (6aS)-
CHEBI:6000
CHEMBL489525
(6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol
Luteanine (VAN)
(S)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol
SR-01000841246
S-Artabotrine
NSC645316
S-Luteanine
(+)-Isocorydin
Prestwick_281
Spectrum_001207
SpecPlus_000517
ISOCORYDINE [MI]
Prestwick0_000597
Prestwick1_000597
Prestwick2_000597
Prestwick3_000597
Spectrum2_000566
Spectrum3_000717
Spectrum4_001699
Spectrum5_000378
BSPBio_000474
BSPBio_002533
KBioGR_001998
KBioSS_001687
MLS002153898
DivK1c_006613
SCHEMBL679908
SPECTRUM1500860
SPBio_000352
SPBio_002693
BPBio1_000522
KBio1_001557
KBio2_001687
KBio2_004255
KBio2_006823
KBio3_001753
DTXSID201023580
HMS1569H16
HMS1921K18
HMS2096H16
HMS2230M17
HMS3886N20
HY-N2591
TNP00260
BDBM50250273
CCG-38732
s9258
STL565301
AKOS015896784
FI66638
SDCCGMLS-0066694.P001
NCGC00016453-01
NCGC00016453-02
NCGC00016453-03
NCGC00016453-04
NCGC00016453-05
NCGC00016453-08
NCGC00142508-01
NCGC00178615-01
NCGC00178615-02
AC-35030
CAS-475-67-2
DA-68973
MS-25214
SMR001233247
CS-0022943
NS00067011
1,2,10-Trimethoxy-6a-alpha-Aporphin-11-ol
C09549
SR-01000841246-3
SR-01000841246-4
BRD-K37049577-001-05-1
BRD-K37049577-001-08-5
Q27106973
6A-.ALPHA.-APORPHIN-11-OL, 1,2,10-TRIMETHOXY-
(9S)-4,15,16-trimethoxy-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaen-3-ol