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Tetrandrine

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Identification
Molecular formula
C38H42N2O6
CAS number
518-34-3
IUPAC name
(6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
State
State

At room temperature, tetrandrine is in a solid state. It is commonly available as a crystalline powder.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.00
Boiling point (Celsius)
394.90
Boiling point (Kelvin)
668.10
General information
Molecular weight
622.77g/mol
Molar mass
622.6880g/mol
Density
1.3347g/cm3
Appearence

Tetrandrine is typically a white or off-white crystalline powder. Depending on the exact form and purity, it can have a slight sheen and may appear slightly granular.

Comment on solubility

Solubility of (6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

The solubility of (6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline can be influenced by several factors. This compound, characterized by its complex polycyclic structure and multiple methoxy groups, is generally considered to possess moderate to low solubility in polar solvents such as water.

Key aspects regarding its solubility include:

  • Polarity: The presence of multiple methoxy groups may enhance its solubility in organic solvents, but restrict its solubility in water due to the hydrophobic nature of the fused ring system.
  • Solvent Interaction: It tends to dissolve well in non-polar or weakly polar organic solvents like methanol, ethanol, and dichloromethane.
  • Hydrogen Bonding: Limited potential for hydrogen bonding with water can further diminish its aqueous solubility.

As a specific indication of its solubility behavior, studies have shown that such complex organic compounds often require increased temperature or specific pH conditions to enhance their solubility. Thus, it is crucial to consider these factors when working with (6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in practical applications.

Interesting facts

Interesting Facts about (6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

The compound known as (6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline is a fascinating member of the dibenzoquinoline family. This compound has garnered significant interest due to its unique structure and potential applications.

Structural Characteristics

  • Complexity: The polycyclic framework of this compound contributes to its intriguing properties. The arrangement of methoxy groups enhances its reactivity and stability.
  • Stereochemistry: The (6aS) configuration indicates chirality, which could lead to different biological activities or interaction with biological systems compared to its enantiomers.

Potential Applications

This compound holds promise in various fields, including:

  • Medicinal Chemistry: Compounds similar to dibenzoquinolines have exhibited interesting pharmacological properties, including anti-cancer, anti-inflammatory, and neuroprotective effects.
  • Organic Synthesis: Due to its unique structure, it can serve as a building block in organic synthesis, potentially leading to new derivatives with enhanced functions.

Research and Study

Studies on compounds like (6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline are critical for understanding their mechanisms of action, effectiveness, and safety. Scientists often focus on:

  • Mechanistic Studies: To unveil how changes in structure alter biological activity.
  • Drug Design: To develop new therapeutics that can target specific diseases effectively.

In conclusion, the compound (6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline serves as an example of the vast potential that complex organic molecules hold in both academic research and practical applications. Its unique properties and structural nuances provide exciting avenues for exploration in scientific fields.

Synonyms
Norglaucin
Norglaucine
21848-62-4
Laurelliptine, O,O'-dimethyl-
(6aS)-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
DTXSID00176254
O,O-Dimethyllaurelliptine
d-N-Norglaucine
(+)-N-Norglaucine
RefChem:1092583
1,2,9,10-Tetramethoxy-6a-alpha-noraporphine
6a-alpha-NORAPORPHINE, 1,2,9,10-TETRAMETHOXY-
orb1680032
DTXCID7098745
CHEBI:181571
MZSUVQFIWWXTFR-AWEZNQCLSA-N
HY-N9339
AKOS040763720
Laurelliptine, O,O'-dimethyl- (7CI)
4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-, (S)-
DA-76264
CS-0159482