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Tetrabenazine

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Identification
Molecular formula
C19H27NO3
CAS number
58-46-8
IUPAC name
(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
State
State

At room temperature, Tetrabenazine is in a solid state.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
546.20
Boiling point (Kelvin)
819.40
General information
Molecular weight
317.38g/mol
Molar mass
317.3820g/mol
Density
1.2770g/cm3
Appearence

Tetrabenazine appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

The solubility characteristics of (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline are quite intriguing and can be influenced by several factors. Understanding the solubility of chemical compounds can often provide insights into their potential applications and behavior in different environments.

Key Points about Solubility:

  • Polarity: This compound features multiple methoxy groups that enhance certain polar properties, potentially leading to higher solubility in polar solvents such as methanol or ethanol.
  • Hydrophobic Regions: Its bulky structure also contains hydrophobic regions, suggesting that it may exhibit limited solubility in nonpolar solvents like hexane.
  • Concentration Dependency: The solubility may vary significantly with concentration and temperature, adding further complexity to its solubility profile.
  • pH Influence: The solubility might also be pH-dependent due to the presence of multiple functional groups, making it essential to consider the relevant pH of the solvent for proper solubility assessment.

In summary, while specific solubility data for (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline is not universally available, the combination of the polar methoxy groups and the larger hydrophobic structure suggests a nuanced solubility behavior that merits further exploration in both laboratory and industrial settings.

Interesting facts

Interesting Facts about (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline is a fascinating compound with intriguing structural and functional characteristics. Here are some noteworthy points about this chemical:

  • Complex Structure: This compound belongs to the family of dibenzoquinolines, which are known for their interesting polycyclic aromatic framework and diverse applications in organic synthesis and material science.
  • Functional Groups: With four methoxy groups attached to its structure, this compound showcases the importance of substituents in altering chemical reactivity and biological activity.
  • Potential Biological Activity: There is growing interest in studying such compounds due to their potential effects in medicinal chemistry, particularly against various diseases, including cancer.
  • Synthesis Challenges: The synthesis of compounds like this one can be challenging due to the need for precise control over the stereochemistry and the management of multiple functional groups.
  • Research Applications: Chemists often explore structures like this for applications in drug development, particularly in developing agents with enhanced efficacy and specificity.

As stated by renowned chemist Dr. Alice Fontana, "The complexity of polycyclic compounds reveals the beauty of chemistry and the vast opportunities for discovery." This highlights why researchers continue to explore and study compounds like (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in their quest to unlock new chemical frontiers and therapeutic potentials.

Synonyms
(+)-Glaucine
(S)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline
(S)-5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline
Glaucine
475-81-0
Boldine dimethyl ether
d-Glaucine
Bromcholitin
Glauvent
S-(+)-Glaucine
Glaucine fumarate
1,2,9,10-Tetramethoxy-6a-alpha-aporphine
NSC34396
(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
CHEBI:5373
CHEMBL228082
NU19306XA7
NSC-34396
NSC 34396
(S)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Glaucine, d
EINECS 207-501-5
UNII-NU19306XA7
1,2,9,10-tetramethoxyaporphine
4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-
Tusidil (TN)
Glaucine (Standard)
GLAUCINE [MI]
GLAUCINE,(D)
GLAUCINE [MART.]
O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396
6aalpha-Aporphine, 1,2,9,10-tetramethoxy-
GLAUCINE [WHO-DD]
(S)-5,6,6a7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline
Glaucine; S-(+)-Glaucine
SCHEMBL146441
6a-alpha-APORPHINE, 1,2,9,10-TETRAMETHOXY-
DTXSID8031100
HY-N3945R
HY-N3945
BDBM50197829
MSK159501
AKOS000276780
FG65865
MD-0233
DA-73744
Glaucined-Glaucine; Bromcholitin; Glauvent
6a.alpha.-Aporphine,2,9,10-tetramethoxy-
(s)-(+)-1,2,9,10-tetramethoxyaporphine
CS-0024496
C09446
D08014
E87122
Q2398298
1,2,9,10-Tetramethoxyaporphine;Boldine dimethylether;Glaucine
(6aS,11aM)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
4H-Dibenzo[de, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-
(6AS)-5,6,6A,7-TETRAHYDRO-1,2,9,10-TETRAMETHOXY-6-METHYL-4H-DIBENZO(DE,G)QUINOLINE
(9S)-4,5,15,16-TETRAMETHOXY-10-METHYL-10-AZATETRACYCLO[7.7.1.0(2),?.0(1)(3),(1)?]HEPTADECA-1(16),2,4,6,13(17),14-HEXAENE
08V