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Mianserin hydrochloride

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Identification
Molecular formula
C18H21ClN2O
CAS number
21535-47-7
IUPAC name
(6aS)-2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-1-ol;chloride
State
State

At room temperature, mianserin hydrochloride is in the solid state. It is typically handled as a powder or a crystalline solid in pharmacological settings.

Melting point (Celsius)
278.00
Melting point (Kelvin)
551.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
393.95g/mol
Molar mass
393.9470g/mol
Density
1.0827g/cm3
Appearence

Mianserin hydrochloride appears as a white to off-white crystalline powder. It is often described as having a relatively fine granularity. The powder is stable under normal conditions and does not have any distinct odor.

Comment on solubility

Solubility of (6aS)-2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-1-ol;chloride

The solubility of the compound (6aS)-2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-1-ol;chloride can be influenced by several factors. Understanding these influences is key for practical applications and experimental work. Here are some important considerations:

  • Polarity: The presence of multiple methoxy groups contributes to its polarity, affecting how it interacts with solvents.
  • Solvent Type: Generally, this compound may demonstrate varying solubility in different solvents. For instance:
    • Highly polar solvents like water may facilitate solubility.
    • Non-polar solvents might yield poor solubility due to the compound's structure.
  • pH Sensitivity: As a quaternary ammonium salt, the solubility might also depend on the pH of the medium, impacting its ionic structure.

Moreover, as the compound is a salt, ionic interactions play a critical role in solubility. For example, the chloride ion can enhance solubility in aqueous solutions.

In conclusion, the solubility of this compound is not straightforward and may vary with the solvent choice and environmental conditions. Experimentation is advised to determine optimal solubility parameters specific to intended applications.

Interesting facts

Interesting Facts about (6aS)-2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-1-ol;chloride

This unique compound belongs to a family of alkaloids, which are naturally occurring organic compounds that often have significant pharmacological effects. Its complex structure features a dibenzoquinoline backbone that contributes to its intriguing biological activity.

Notable Characteristics:

  • Biological Activity: Various studies suggest that this compound may possess potent effects on the central nervous system (CNS). It has been researched for potential applications in treating neurological disorders.
  • Dimethoxy Groups: The presence of two methoxy groups enhances the molecule’s lipophilicity, which can influence its ability to cross the blood-brain barrier and interact with target receptors.
  • Structural Complexity: The tetrahydro configuration introduces flexibility in the molecule, enabling it to interact with multiple biological targets through various conformations.

As a chemist or student, one might find it fascinating how the intricate design of such compounds can lead to major breakthroughs in medicinal chemistry. The combination of aromatic rings and complex cyclic systems is a common theme in drug discovery, particularly in the quest for CNS-active agents. Researchers continue to explore similar structures in hopes of developing new therapeutic drugs that could treat conditions like depression, anxiety, or other neurological ailments.

In conclusion, the study of (6aS)-2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-1-ol;chloride serves as a remarkable example of how intricate chemical frameworks can lead to significant advancements in health sciences. Understanding its properties, potential mechanisms of action, and synthesis methods could prove pivotal in shaping future medicinal applications.

Synonyms
Isothebaine hydrochloride
2,11-Dimethoxy-6a-alpha-aporphin-1-ol hydrochloride
6a-alpha-APORPHIN-1-OL, 2,11-DIMETHOXY-, HYDROCHLORIDE
4H-Dibenzo(de,g)quinolin-1-ol, 5,6,6a,7-tetrahydro-2,11-dimethoxy-6-methyl-, HCl, (S)-
25650-97-9
RefChem:309446