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Methadone hydrochloride

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Identification
Molecular formula
C21H28ClNO
CAS number
1095-90-5
IUPAC name
(6R)-6-(dimethylamino)-4,4-diphenyl-heptan-3-one;hydrochloride
State
State

At room temperature, Methadone hydrochloride is typically in a solid state. It is provided in various forms for medical use, including as a powder or tablet, and is designed for solubility in liquid solutions.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
345.91g/mol
Molar mass
345.9060g/mol
Density
0.9850g/cm3
Appearence

Methadone hydrochloride typically appears as white crystalline powder. It is soluble in water and is often provided in tablet, powder, or liquid forms for medical use.

Comment on solubility

Solubility of (6R)-6-(dimethylamino)-4,4-diphenyl-heptan-3-one hydrochloride

The solubility of the compound (6R)-6-(dimethylamino)-4,4-diphenyl-heptan-3-one hydrochloride can be influenced by several factors, making it important for both theoretical research and practical applications. Here are some key points to consider:

  • Polar Nature: As a hydrochloride salt, this compound is expected to be more soluble in polar solvents such as water due to the presence of ionic interactions.
  • Temperature Dependency: The solubility is likely to increase with an increase in temperature, which is typical for many solids.
  • pH Influence: The solubility can also be affected by the pH of the solution. Higher pH levels may lead to changes in solubility for amines.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds with solvents contributes to its solubility profile, particularly in water.

In summary, one can expect that (6R)-6-(dimethylamino)-4,4-diphenyl-heptan-3-one hydrochloride is soluble in polar solvents primarily due to its ionic nature, with solubility being influenced by temperature, pH, and the potential for hydrogen bonding.

Interesting facts

Interesting Facts about (6R)-6-(dimethylamino)-4,4-diphenyl-heptan-3-one; hydrochloride

This compound, commonly referred to in its hydrochloride salt form, is notable for its pharmacological properties. It serves as a crucial subject of study within the field of medicinal chemistry. Here are some compelling facts:

  • Pharmacological Role: The compound has been explored for its potential roles in treating various conditions, particularly in the realm of neuropharmacology. Its *dimethylamino* group is integral to its efficacy in influencing neurotransmitter systems.
  • Isomeric Properties: As a compound with chiral centers, its (6R) configuration is particularly significant. The specific stereo-configuration can greatly influence its biological activity, demonstrating the principle that *structure determines function* in chemistry.
  • Reaction Mechanisms: Chemists studying this compound often delve into its reaction mechanisms, elucidating how it interacts with other biological molecules. Understanding these mechanisms is vital for developing safer and more effective pharmaceuticals.
  • Analytical Techniques: The characterization of this compound relies heavily on advanced analytical techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography. These tools help chemists confirm its identity and understand its properties.
  • Potential Applications: Beyond its immediate pharmacological uses, compounds of this class can lead to the discovery of new drugs. The ongoing research into similar structures can unveil treatments for various ailments, including psychiatric disorders and neurodegenerative diseases.

In conclusion, (6R)-6-(dimethylamino)-4,4-diphenyl-heptan-3-one; hydrochloride is more than just a chemical entity—it embodies the intricate relationship between molecular structure and biological function. As research continues, this compound may lead to breakthroughs in therapeutic applications that enhance quality of life for many patients.

Synonyms
Levomethadone hydrochloride
l-Methadone hydrochloride
l-Polamidon hydrochloride
l-Amidone hydrochloride
5967-73-7
l-Dolophine hydrochloride
Methadone hydrochloride, L-
(-)-Methadone hydrochloride
Methadone HCl l-form
Methadone hydrochloride l-form
levomethadone HCl
EINECS 227-756-6
L-polamidon (TN)
UNII-V57LC776C0
V57LC776C0
l-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride
1,1-Diphenyl-1-(2-dimethylaminopropyl)-2-butanone
3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (R)-
3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE, (-)-
METHADONE L-FORM HYDROCHLORIDE
D-(-)-METHADONE HYDROCHLORIDE
(6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one hydrochloride
LEVOMETHADONE HYDROCHLORIDE [MART.]
METHADONE L-FORM HYDROCHLORIDE [MI]
LEVOMETHADONE HYDROCHLORIDE [WHO-DD]
LEVOMETHADONE HYDROCHLORIDE [EP MONOGRAPH]
3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE (1:1), (6R)-
LEVOMETHADONE HYDROCHLORIDE (MART.)
LEVOMETHADONE HYDROCHLORIDE (EP MONOGRAPH)
227-756-6
(6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride
(R)-Dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride
SCHEMBL396161
DTXSID30975070
FJQXCDYVZAHXNS-UNTBIKODSA-N
D08122
(R)-Methadone Hydrochloride (1.0mg/ml in Methanol)
Q27291550
6-(Dimethylamino)-4,4-diphenylheptan-3-one--hydrogen chloride (1/1)