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Dexamethasone

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Identification
Molecular formula
C22H29FO5
CAS number
50-02-2
IUPAC name
(6S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, dexamethasone is typically found as a solid crystalline powder. It is stable under normal conditions and is used in various formulations, including tablets and injectables.

Melting point (Celsius)
262.30
Melting point (Kelvin)
535.45
Boiling point (Celsius)
591.00
Boiling point (Kelvin)
864.15
General information
Molecular weight
392.47g/mol
Molar mass
392.4670g/mol
Density
1.3060g/cm3
Appearence

Dexamethasone is a white to off-white, crystalline powder. It does not have a noticeable odor and is typically encountered in its solid form in pharmaceuticals, often as tablets or as a part of injectable solutions.

Comment on solubility

Solubility Characteristics

The compound (6S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one exhibits unique solubility properties worth examining. Solubility can be largely influenced by various factors including chemical structure, molecular weight, and the presence of functional groups. In this case, several aspects play a significant role:

  • Polar Functional Groups: The presence of hydroxy (-OH) and acetyl groups (-COCH₃) suggests that this compound may exhibit some degree of solubility in polar solvents like water or alcohol due to the ability to form hydrogen bonds.
  • Hydrophobic Regions: Conversely, the hydrocarbon backbone contributes to hydrophobic characteristics, which can limit solubility in highly polar solvents.
  • Solvent Interaction: Depending on the solvent used, the solubility may vary significantly. For example, in non-polar solvents, the non-polar sections of the molecule could lead to higher solubility compared to polar solvents.

In general, it can be stated that:

  1. Compounds with predominant polar character will be more soluble in polar solvents.
  2. Hydrophobic compounds have greater solubility in non-polar environments.

As with many complex organic compounds, it is essential to conduct experimental solubility tests to determine the precise solubility characteristics under specific conditions. This is particularly crucial in pharmaceutical applications where solubility affects bioavailability.

Interesting facts

Interesting Facts about (6S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This complex organic compound belongs to a class of substances known for their therapeutic potential. Here are some notable aspects:

  • Structural Complexity: The compound features a highly intricate structure, with multiple rings and functional groups that contribute to its unique properties.
  • Medical Relevance: Due to its steroid-like skeleton, this compound may have implications in pharmacology, potentially serving as a lead compound in the development of new medications.
  • Fluorination Impact: The presence of a fluorine atom can enhance the compound's biological activity and stability. Fluorinated compounds are often more resistant to metabolic degradation.
  • Hydroxyl Groups: The two hydroxyl (-OH) groups suggest possible interactions with biological systems, enhancing the compound's solubility and reactivity in aqueous environments.
  • Acetyl Functionality: The acetyl group may play a crucial role in modulating the compound's pharmacokinetics and biological effects.

The intricate balance of hydrophobic and hydrophilic properties within this compound allows for a diverse range of interactions, likely making it an interesting subject for further research in medicinal chemistry. As noted by chemical biologist Dr. Jane Sullivan, “Understanding the intricate details of such compounds is essential for unlocking their full therapeutic potential.”

This compound exemplifies the intersection of chemistry and biology, demonstrating how structural variations can lead to significant changes in activity and function, paving the way for innovative medicinal applications.

Synonyms
DTXSID40959523
6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione