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Budesonide

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Identification
Molecular formula
C25H34O6
CAS number
51333-22-3
IUPAC name
(6S,7R,9R)-6-hydroxy-15-[(1R,2R)-2-hydroxy-1-methyl-3-(4-methyl-5-oxo-2H-furan-3-yl)propyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one
State
State

Budesonide is typically found in a solid state at room temperature.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
430.53g/mol
Molar mass
430.5340g/mol
Density
0.1630g/cm3
Appearence

Budesonide is a white to off-white crystalline powder. It is practically insoluble in water and soluble in alcohol and acetone.

Comment on solubility

Solubility Characteristics

The solubility of the compound (6S,7R,9R)-6-hydroxy-15-[(1R,2R)-2-hydroxy-1-methyl-3-(4-methyl-5-oxo-2H-furan-3-yl)propyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one can be influenced by various factors including its molecular structure and the presence of functional groups. Here are some key points to consider:

  • Polarity: The presence of hydroxyl groups contributes to a certain degree of polarity, which can enhance solubility in polar solvents like water.
  • Hydrophobic Regions: The larger hydrophobic segments of the molecule may limit its solubility in highly polar solvents.
  • Solvent Interaction: The solubility can significantly vary depending on the solvent used. For example, it may be better soluble in organic solvents such as ethanol or methanol compared to water.
  • pH Dependency: The acidity or basicity of the solution may also affect solubility, especially due to the presence of functional groups susceptible to protonation or deprotonation.

In general, predicting solubility for complex organic compounds can be challenging, but understanding the molecular interactions can provide insights. As the saying goes, "like dissolves like," reinforcing the idea that compounds tend to be more soluble in solvents of similar polarity.

Overall, while extensive empirical data may be required to quantify the solubility of this specific compound, these principles can guide expectations regarding its solubility behavior in different environments.

Interesting facts

Interesting Facts about (6S,7R,9R)-6-hydroxy-15-[(1R,2R)-2-hydroxy-1-methyl-3-(4-methyl-5-oxo-2H-furan-3-yl)propyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one

This remarkable compound, known for its intricate structure and unique properties, belongs to a class of compounds often studied for their bioactive potential. The presence of multiple chiral centers and functional groups adds to its complexity and versatility. Here are some fascinating insights into this compound:

  • Chirality and Stereochemistry: The compound's stereochemistry is significant, influencing its biological activity and interactions in various applications. The specific orientations of the hydroxyl groups and the methyl substituents can lead to pronounced differences in behavior.
  • Bioactivity: Many compounds with similar structures are researched for their therapeutic effects, particularly in fields such as pharmacology and medicinal chemistry. This compound's unique formulation may suggest potential antiproliferative or anti-inflammatory properties.
  • Complexity of Pentacyclic Structure: The pentacyclic framework is both a chemical marvel and a point of interest. Studying this framework helps chemists understand how complex polycyclic compounds can be synthesized and functionalized.
  • Potential in Natural Product Chemistry: Compounds like this often derive inspiration from nature, prompting studies into their ecological roles and applications in drug discovery. Natural product chemists are particularly interested in such structures for their ability to model biologically active systems.
  • Research and Development: Ongoing research into compounds with intricate molecular structures, like this one, may lead to breakthroughs in drug development and innovative applications in various fields, including agriculture and environmental science.

The synthesis and characterization of such complex compounds continue to challenge and excite chemists, pushing the boundaries of organic synthesis and structural analysis. As we delve deeper into the study of this compound, we uncover not only the beauty of chemistry but also the potential for transformative applications.

Synonyms
SCHEMBL23924331