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Cefaclor

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Identification
Molecular formula
C15H14ClN3O4S
CAS number
53994-73-3
IUPAC name
(6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;2-aminoethanol
State
State

At room temperature, cefaclor is in a solid state, specifically as a crystalline powder. This physical form makes it suitable for compounding into oral dosage forms like tablets and capsules used for therapeutic applications.

Melting point (Celsius)
160.50
Melting point (Kelvin)
433.65
Boiling point (Celsius)
540.00
Boiling point (Kelvin)
813.15
General information
Molecular weight
367.40g/mol
Molar mass
367.4040g/mol
Density
1.4500g/cm3
Appearence

Cefaclor generally appears as a white to off-white crystalline powder. It can be characterized by its lack of smell and a slightly bitter taste. When finely powdered, this compound reveals uniformity in its texture and lends itself well to the process of tablet or capsule formulation for pharmaceutical applications.

Comment on solubility

Solubility of (6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 2-aminoethanol

The solubility of this compound is influenced by several factors, including its chemical structure and the presence of functional groups. Here are some key points to consider:

  • Polarity: The presence of polar functional groups, such as the acetoxymethyl and carboxylic acid groups, suggests increased solubility in polar solvents, like water.
  • Hydrogen Bonding: The capability of the compound to engage in hydrogen bonding can enhance solubility. The hydroxyl group from 2-aminoethanol may further improve interactions with water.
  • Hydrophobic Interactions: The thienyl and bicyclic structure may introduce some hydrophobic characteristics, potentially decreasing solubility in non-polar solvents.
  • pH Dependency: The solubility of carboxylic acids is often pH-dependent; at lower pH levels, the acid may remain protonated and reduce solubility.

Overall, while this compound may exhibit reasonable solubility in polar solvents due to its functional groups, the presence of hydrophobic regions could limit solubility in non-polar environments. Thus, understanding the context of intended use is crucial for predicting solubility behaviors. Always consider the solvent environment when assessing solubility!

Interesting facts

Interesting Facts about (6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;2-aminoethanol

This compound, which is a derivative of a bicyclic structure, showcases the fascinating intersection of organic chemistry and medicinal applications. Here are some engaging insights:

  • Novel Antibiotic Potential: The unique structure of this compound suggests promising antibiotic properties. Researchers are investigating its efficacy against various bacterial strains, particularly those resistant to conventional antibiotics.
  • Complex Synthesis: The synthesis of this compound is a challenging endeavor that often requires multiple steps and intricate reaction conditions. It exemplifies the art of organic synthesis and the creativity of chemists.
  • Functional Groups: The presence of multiple functional groups, including an acetoxymethyl group and a thienyl acetyl moiety, highlights the compound's versatility and the potential for a variety of chemical reactions.
  • Therapeutic Applications: Given its structure, it is being closely examined for anti-inflammatory and analgesic effects, opening new pathways for treating chronic pain.
  • Structural Diversity: The bicyclic core, along with the thio group, yields a complex three-dimensional arrangement, making it a subject of interest in medicinal chemistry for drug design.

In summary, this compound is not just another marker in the vast landscape of chemical compounds; it offers significant insights into potential breakthroughs in the world of pharmaceuticals and serves as a testament to the ongoing research in medicinal chemistry. As a student or scientist, exploring its properties can illuminate the path toward developing more effective therapeutic agents.