Skip to main content

Cefotaxime

ADVERTISEMENT
Identification
Molecular formula
C16H17N5O7S2
CAS number
63527-52-6
IUPAC name
(6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
State
State

At room temperature, cefotaxime is a solid and is usually used in its powder form, particularly for the preparation of injectable solutions in medical settings.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
455.44g/mol
Molar mass
455.4350g/mol
Density
1.5500g/cm3
Appearence

Cefotaxime is typically found as a white to off-white crystalline powder. It is known for its solubility in water and slight solubility in methanol. As a solid, it may also come in the form of a lyophilized powder for pharmaceutical use.

Comment on solubility

Solubility of (6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

The solubility characteristics of (6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid are influenced by several structural factors. Here are key points regarding its solubility:

  • Apolar solvents: This compound is likely to exhibit limited solubility in apolar solvents due to its complex large structure, which contains both hydrophilic and lipophilic regions.
  • Aqueous solutions: The presence of the carboxylic acid group suggests some degree of solubility in water. The carboxylic acid functionality is generally associated with increased solubility in polar solvents.
  • Influence of substituents: The acetoxymethyl and thienyl groups can further affect solubility. As substituents introduce additional polar character, they may enhance overall aqueous solubility.
  • pH dependence: The solubility of the acid form can vary significantly with pH; at higher pH levels, deprotonation may enhance solubility due to resulting charged species.

Overall, the solubility profile of this compound is complex and reflects its intricate molecular structure. As mentioned, the solubility will be significantly affected by the solvent choice and environmental conditions like pH.

Interesting facts

Exploring (6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6S,7S)-3-(acetoxymethyl)-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a fascinating compound that belongs to a class of chemicals known for their significant biological activity and capability of influencing various biochemical pathways. Here are some interesting aspects of this compound:

  • Unique Structure: The compound features a bicyclic structure, which is essential for its biological function. Its 5-thia ring and azabicyclic framework are characteristics that contribute to its reactivity and interactions with biological targets.
  • Thienyl Group: The presence of a thienyl group offers intriguing properties, enhancing potential biological activity and allowing for various modifications that can tailor its specialist applications in medicinal chemistry.
  • Biological Implications: Compounds like this one often showcase antibiotic or enzyme inhibiting activities. Research into its specific interactions could lead to innovations in antibiotic treatment and drug design.
  • Synthetic Bioactivity: The synthesis of such compounds often involves complex pathways, highlighting the innovative techniques in organic chemistry that can yield functional molecules with pragmatic uses in pharmaceuticals.
  • Potential Applications: This compound’s characteristic structure enables it to possibly serve as a scaffold for deriving new therapeutic agents, particularly in treating bacterial infections or specific biochemical pathways.

In summary, the compound is not only a testament to the fascinating world of organic chemistry but also a potential key player in developing new medicinal remedies. The integration of various functional groups illustrates the exciting possibilities that continue to be explored in scientific research and pharmaceutical development.

Synonyms
AKOS025402327
AC-8138