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Dexamethasone acetate

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Identification
Molecular formula
C24H31FO6
CAS number
1177-87-3
IUPAC name
[(6S,9R,11S,14S,16R,17R)-6,9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
State
State

At room temperature, dexamethasone acetate exists in a solid state as a crystalline powder. The solid is typically stable under normal conditions of temperature and pressure.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.15
Boiling point (Celsius)
529.40
Boiling point (Kelvin)
802.50
General information
Molecular weight
434.51g/mol
Molar mass
434.4600g/mol
Density
1.3150g/cm3
Appearence

The compound is generally a white or slightly off-white crystalline powder that is odorless. It can appear as crystalline solids that may clump together. It is often distributed in the form of tablets or injectable solutions for medical use.

Comment on solubility

Solubility Insights

The solubility of the compound [(6S,9R,11S,14S,16R,17R)-6,9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate is influenced by several key factors:

  • Polarity: Due to the presence of hydroxyl groups and ester functionalities, this compound may exhibit varying degrees of polarity, affecting its interaction with solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility in polar solvents such as water, especially with the hydroxyacetyl moiety contributing to favorable solvation.
  • Hydrophobicity: The larger hydrocarbon regions in the structure may lead to increased hydrophobic character, potentially reducing solubility in polar environments but enhancing it in non-polar solvents.
  • Temperature: As with many organic compounds, solubility may increase with temperature, which can facilitate the dissolution process.

In summary, the solubility behavior of this complex compound is likely to be multifaceted, depending on solvent polarity, temperature, and molecular interactions. Understanding these characteristics can guide effective usage and application in various chemical environments.

Interesting facts

Interesting Facts about the Compound

This fascinating compound, known for its complex structure and rich functionalization, belongs to a class of substances that play significant roles in biological systems and medicinal chemistry. Here are some noteworthy points about this intriguing compound:

  • Stereochemistry: The stereochemistry of this compound is particularly captivating. With multiple chiral centers, it exemplifies how small changes in the spatial arrangement of atoms can lead to vastly different biological activities.
  • Biological Relevance: Compounds like this one, often derived from natural products, may exhibit important pharmacological properties. They are frequently studied for their potential therapeutic effects, including anti-inflammatory and anticancer activities.
  • Functional Groups: The presence of various functional groups, such as hydroxyl and acetyl moieties, enhances its reactivity and versatility. This opens pathways for further chemical modifications, potentially leading to novel derivatives with tailored functions.
  • Structure Activity Relationship (SAR): Understanding the structure-activity relationship is vital in medicinal chemistry. This compound's intricate structure allows chemists to investigate how specific parts of the molecule contribute to its activity, guiding the design of more effective drugs.
  • Synergistic Effects: When studied alongside other compounds, this compound may demonstrate synergistic effects, where the combined action of multiple agents results in enhanced therapeutic efficacy, a principle often explored in combination therapy approaches.
  • Future Research: Ongoing research is devoted to uncovering the full potential of such complex organic molecules. Scientists continually seek to elucidate their mechanisms of action, which might lead to breakthrough therapies in various medical fields.

As we continue to explore the biochemical pathways affected by such compounds, understanding their unique features is essential for the advancement of drug discovery and development.