Skip to main content

Fluticasone Propionate

ADVERTISEMENT
Identification
Molecular formula
C25H31ClF2O5
CAS number
80474-14-2
IUPAC name
(6S,9R,16R)-9-chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, Fluticasone Propionate is in a solid state, specifically a crystalline powder.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
197.50
Boiling point (Kelvin)
470.65
General information
Molecular weight
500.58g/mol
Molar mass
500.5750g/mol
Density
1.4900g/cm3
Appearence

Fluticasone Propionate appears as a white to off-white powder. It is odorless and stable under normal conditions.

Comment on solubility

Solubility Insights

The solubility of the compound (6S,9R,16R)-9-chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta [a]phenanthren-3-one can be explored from several angles:

  • Polarity: The presence of polar functional groups such as hydroxyl (-OH) and carbonyl (-C(=O)) groups often enhances solubility in hydrophilic (water) solvents.
  • Hydrophobic Regions: The large hydrophobic hydrocarbon skeleton may reduce solubility in water, while affecting solubility in organic solvents.
  • Solvent Compatibility: This compound may show better solubility characteristics in non-polar or slightly polar organic solvents like ethanol or DMSO, owing to its hydrophobic regions.
  • Temperature Influence: Increased temperature can generally increase solubility for many organic compounds, suggesting that variations in temperature could affect this compound's solubility.

Overall, understanding the balance between hydrophilic and hydrophobic characteristics is pivotal in predicting this compound's solubility behavior in different environments.

Interesting facts

Compound Overview

The compound known as (6S,9R,16R)-9-chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one is a complex organic molecule that belongs to a class of compounds known for their biological activity.

Interesting Facts

Here are some intriguing elements surrounding this chemical compound:

  • Steroid Framework: The structure of this compound features a steroid-like backbone, which is prevalent in many biologically active molecules. These steroid frameworks are often crucial for their interaction with biological receptors.
  • Biological Activity: Compounds of this nature may possess significant pharmacological properties, potentially influencing various biological pathways, including anti-inflammatory and anti-cancer effects.
  • Functional Groups: The presence of halogen atoms (like chlorine and fluorine) in the compound can enhance its biological activity and lipophilicity, making it more effective in certain therapeutic settings.
  • Hydroxy and Acetyl Groups: The hydroxyl groups are often involved in hydrogen bonding, which aids in the solubility and interaction of the molecule with biological macromolecules.

As ongoing research continues to uncover the potential uses of such compounds, they may serve as a template for designing new drugs or therapeutic agents.

Conclusion

In summary, (6S,9R,16R)-9-chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one is a compound rich with opportunities for investigation. The molecular complexity opens the door to a variety of practical applications in medicinal chemistry.

Synonyms
CHEMBL63427
SCHEMBL1649617