Skip to main content

Dexamethasone acetate

ADVERTISEMENT
Identification
Molecular formula
C24H31Cl2FO6
CAS number
1177-87-3
IUPAC name
(6S,9R,16R,17R)-9,11-dichloro-6-fluoro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
State
State
At room temperature, it is typically found as a solid.
Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
573.20
Boiling point (Kelvin)
846.30
General information
Molecular weight
434.94g/mol
Molar mass
434.9400g/mol
Density
1.5000g/cm3
Appearence
The compound generally appears as a white to off-white crystalline powder.
Comment on solubility

Solubility Insights

The solubility of the compound (6S,9R,16R,17R)-9,11-dichloro-6-fluoro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one is nuanced and can be influenced by various factors. Here are some key points to consider:

  • Polarity: The presence of functional groups such as hydroxyl and acetyl suggests that the compound may exhibit some degree of polarity, potentially increasing its solubility in polar solvents such as water.
  • Organic Solvents: Compounds with similar structures often show better solubility in organic solvents like ethanol, methanol, or dimethyl sulfoxide (DMSO), which may dissolve non-polar regions effectively.
  • Temperature Effects: Solubility is typically temperature-dependent. Increased temperatures can lead to higher solubility for many compounds, potentially making dissolution easier.
  • pH Influence: The acidic or basic nature of the solution can also affect solubility, especially for compounds with ionizable groups like hydroxyls.
  • Crystallinity: The crystalline form of the compound can impact its solubility. Amorphous forms often exhibit higher solubility compared to their crystalline counterparts.

In summary, while the solubility of this complex compound may be enhanced in polar solvents due to its hydroxyl and acetyl groups, the precise solubility will ultimately depend on the solvent characteristics, temperature, and physical state of the compound. Exploring these aspects will provide a comprehensive understanding of its solubility behaviors.

Interesting facts

Exploring the Compound: (6S,9R,16R,17R)-9,11-Dichloro-6-fluoro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

This compound is a fascinating example of a complex organic molecule that belongs to the family of synthetic steroids. Steroid-like compounds have been pivotal across various fields, particularly in medicinal chemistry and biology. Here are some key points to note about this particular compound:

  • Stereochemistry: The compound features multiple stereocenters, highlighted by the (6S,9R,16R,17R) configuration, which significantly contributes to its biological activity and interaction with biological receptors.
  • Chlorine and Fluorine Atoms: The presence of halogen substitutes (dichloro and fluoro groups) can enhance lipophilicity and biological action, making this compound potentially unique in therapeutic applications.
  • Hydroxyl Groups: The compound contains hydroxyl (–OH) and acetyl functionalities, which can influence solubility and reactivity, as well as contribute to hydrogen bonding interactions with biomolecules.
  • Role in Drug Development: Complex compounds like this one can serve as precursors for designing novel drugs, with potential applications in treating various diseases, including cancers and endocrine disorders.
  • Structural Complexity: The intricate arrangement of rings in its structure, characterized by the octahydrocyclopenta[a]phenanthren moiety, is indicative of a sophisticated synthetic pathway, showcasing the ingenuity required in organic synthesis.

This compound exemplifies the intersection of chemistry and medicine, demonstrating the importance of molecular modifications in enhancing the effectiveness and specificity of pharmaceuticals. As advancements in synthetic methods continue, the study of such complex molecules can lead to significant breakthroughs in drug design and therapeutic efficacy. "The beauty of chemistry lies not just in its simplicity but in the endless possibilities of complex interplay between atoms within a molecule."