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Gemifloxacin

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Identification
Molecular formula
C18H20FN5O4
CAS number
175463-14-6
IUPAC name
7-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid
State
State

At room temperature, Gemifloxacin is typically a solid.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
389.39g/mol
Molar mass
389.3940g/mol
Density
1.4000g/cm3
Appearence

Gemifloxacin appears as a crystalline solid. It typically presents as a white to pale yellow powder.

Comment on solubility

Solubility of 7-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid

The solubility of the compound with the chemical formula C18H20FN5O4 is a critical aspect that underscores its potential application in various fields. Solubility can affect a compound's bioavailability, which is vital in medicinal chemistry for drug formulations.

This particular compound is characterized by several functional groups which influence its solubility profile:

  • Quinoline structure: Typically, quinoline derivatives can exhibit varying solubility in both polar and non-polar solvents.
  • Fluoro group: The presence of fluorine can increase polarity, potentially enhancing solubility in polar solvents.
  • Carboxylic acid group: The carboxylic group is highly polar and typically increases water solubility, especially under ionized conditions.
  • Methoxy group: The methoxy group can introduce some non-polar characteristics, which may affect overall solubility in mixed solvent systems.

Given these considerations, one can generally expect that:

  • If assessed in water, the ionization of the carboxylic acid may lead to a significant increase in solubility.
  • In organic solvents, solubility could vary widely depending on the solvent's polarity and the presence of hydrogen bonding capabilities.

In conclusion, the interplay of various substituents on the compound's structure suggests that it may have favorable solubility in both polar and non-polar environments. Ultimately, experimental determination is essential to fully characterize its solubility under specific conditions.

Interesting facts

Exploring the Compound: 7-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid

This fascinating compound belongs to a class of quinolines, which are known for their diverse pharmacological properties. With its intricate structure, it combines multiple functional groups that contribute to its unique characteristics. Here are some interesting facts:

  • Biological Activity: Compounds similar to this one have been studied for their potential use as antimicrobial agents. Their complex structures may enhance interactions with biological targets, leading to effective treatments.
  • Structural Diversity: The presence of the octahydropyrrolo moiety not only increases the molecular complexity but may also influence the stereochemistry, which plays a critical role in determining the biological activity of the compound.
  • Fluoro-Substitution: The inclusion of a fluoro group is particularly noteworthy. Fluorinated compounds often exhibit enhanced metabolic stability and can modulate the biological activity due to the unique electronic properties of fluorine.
  • Potential Applications: Given its structural features, this compound may hold promise in the development of new therapeutic agents targeting various diseases, particularly those related to the nervous system and infectious agents.

As scientists and researchers delve deeper into the properties and applications of such compounds, they continue to uncover their potential roles in medicine and beyond. With complex structures often come complex interactions with biological systems, making the study of this compound an exciting field of inquiry.

Synonyms
354812-41-2
(Rac)-Moxifloxacin
CID 4259
1-cyclopropyl-6-fluoro-8-methoxy-7-(octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
7-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4 -oxo-quinoline-3-carboxylic acid
1-CYCLOPROPYL-7-(2,8-DIAZABICYCLO[4.3.0]NON-8-YL)-6-FLUORO-8-METHOXY-4-OXOQUINOLINE-3-CARBOXYLIC ACID
158060-78-7
1-Cyclopropyl-6-fluoro-7-((4aS,7aS)-hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-7-(hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-cyclopropyl-6-fluoro-8-methoxy-7-{octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-
7-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-
(4R,7R)-Moxifloxacin
SCHEMBL1883937
DTXSID30861404
Moxifloxacin [Non-stereospecific]
WDC74714
HY-66011B
STL483394
AKOS025149634
SB73137
NCGC00389526-01
DA-49153
FC102529
CS-0099511
NS00099832
C07663
1-cyclopropyl-6-fluoro-7-{hexahydro-1h-pyrrolo-[3,4-b]pyridin-6(2h)-yl}-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid