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Cefotaxime

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Identification
Molecular formula
C16H17N5O7S2
CAS number
63527-52-6
IUPAC name
7-[[2-(2-aminothiazol-4-yl)-1-hydroxy-2-nitroso-vinyl]amino]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
State
State

At room temperature, cefotaxime is in a solid state as a powder. It is stable under normal temperatures and pressures, but as with many antibiotics, it should be protected from light and moisture to maintain its stability.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
518.30
Boiling point (Kelvin)
791.50
General information
Molecular weight
455.45g/mol
Molar mass
455.4500g/mol
Density
1.5800g/cm3
Appearence

Cefotaxime is typically a white or slightly yellow crystalline powder. It is usually supplied in a powdered form that is reconstituted into an injectable solution for medical use.

Comment on solubility

Solubility of 7-[[2-(2-aminothiazol-4-yl)-1-hydroxy-2-nitroso-vinyl]amino]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

The solubility of the compound C16H17N5O7S2 is influenced by several factors:

  • Polarity: Given the presence of polar functional groups such as the amino, hydroxy, and carboxylic acid moieties, this compound is likely to exhibit moderate to high solubility in polar solvents, particularly in water.
  • Hydrogen Bonding: The capability of this compound to engage in hydrogen bonding due to -OH and -NH groups may further enhance solubility in aqueous environments.
  • pH Dependence: As a carboxylic acid, its solubility may also be affected by the pH of the solution, becoming more soluble in basic conditions due to dissociation.
  • Molecular Weight: With a molecular weight around 397.45 g/mol, typically, higher molecular weight compounds exhibit lower solubility; however, the specific structural features of this compound must also be considered.

In summary, while a definitive solubility value is not readily available, the presence of polar functional groups suggests that the compound could have favorable solubility characteristics in appropriate solvent systems, particularly in polar solvents such as water. Understanding the solubility behavior is crucial for applications in pharmaceuticals and chemical synthesis, where effective dissolution can enhance bioavailability and reaction efficiency.

Interesting facts

Interesting Facts about 7-[[2-(2-Aminothiazol-4-yl)-1-hydroxy-2-nitroso-vinyl]amino]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

This intriguing compound belongs to a class of chemical entities that could play significant roles in medicinal chemistry and pharmacology. Here are some interesting facts about it:

  • Structure and Complexity: The compound boasts a unique bicyclic structure that contributes to its interesting chemical properties. The presence of multiple functional groups, including nitroso and amino moieties, considerably enhances its reactivity and potential biological activity.
  • Potential Biological Activity: Compounds featuring thiazole rings are often investigated for their antimicrobial and anti-inflammatory properties. This compound, due to its structural features, may exhibit similar medicinal properties and warrants further research into its pharmacological potential.
  • Synthetic Pathways: The synthesis of such complex molecules often involves multiple steps and carefully controlled reaction conditions, showcasing the impressive capabilities of organic synthesis in modern chemistry.
  • Applications in Research: Compounds like this one are not just of academic interest but may pave the way for the development of new drugs. The combinatorial chemistry approach, which can involve modifying base structures to optimize efficacy, can significantly extend the applications of such compounds.
  • Interdisciplinary Implications: The study of this compound crosses the boundaries of chemistry, biology, and pharmacology, making it relevant for drug discovery and development processes. It serves as a perfect example of how multidisciplinary approaches can facilitate advancements in therapeutics.

As we delve deeper into the structural characteristics and potential applications, this compound stands as a testament to the **complexity** and **richness** of chemical research. The journey from synthesis to application could yield fascinating insights and transformative solutions in the medical field.