Skip to main content

Ceftazidime

ADVERTISEMENT
Identification
Molecular formula
C22H22N6O7S2
CAS number
72558-82-8
IUPAC name
7-[[2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl-ethoxy)imino-acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, Ceftazidime is present in a solid state. It is commonly formulated as a sodium salt for increased solubility and is administered intravenously or intramuscularly after reconstitution from its powder form.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
546.59g/mol
Molar mass
546.5850g/mol
Density
1.5000g/cm3
Appearence

Ceftazidime is typically found as a white to cream-colored, crystalline powder. It is an antibiotic used to treat a wide variety of bacterial infections. As a powder, it is usually reconstituted before administration.

Comment on solubility

Solubility Characteristics

The solubility of the compound with the formula C22H22N6O7S2 is influenced by its complex structure and the presence of various functional groups. Here are some important points to consider:

  • Polar and Non-Polar Interactions: The compound contains both polar and non-polar sections, which can affect its solubility in different solvents.
  • Functional Groups: The presence of the carboxylate group (-COO-) typically enhances solubility in polar solvents such as water.
  • Aromatic Systems: The pyridine ring in the structure may contribute to solvation properties and affect interactions with solvents.
  • Amino and Thiazole Groups: These groups can engage in hydrogen bonding, potentially increasing solubility in polar environments.

Overall, it can be expected that this compound will exhibit variable solubility depending on the solvent:

  1. Water: Likely soluble due to the presence of polar functional groups.
  2. Organic Solvents: Solubility might decrease in non-polar solvents due to the compound's more polar characteristics.

In summary, the solubility of this compound is multifaceted and emphasizes the importance of considering both its chemical structure and the properties of potential solvents. Understanding these interactions is crucial for applications in the fields of chemistry and pharmacology.

Interesting facts

Interesting Facts About the Compound

This compound, known for its complex structure, showcases the fascinating interplay of organic chemistry and medicinal applications. Here are some engaging insights:

  • Composition Diversity: It contains a variety of functional groups such as thiazole, pyridine, and oxo moieties which contribute to its biological activity.
  • Medicinal Potential: Compounds like this one are often investigated for their antimicrobial and anti-inflammatory properties. Their intricate designs can interact with biological targets, which is crucial for developing effective pharmaceuticals.
  • Bicyclic Structure: The presence of a bicyclic system allows for unique stereochemistry and might enhance the compound's ability to fit into specific biological receptors.
  • Research Frontiers: Scientists are continually exploring similar compounds for their potential as new drug candidates. This compound's complexity makes it a subject of interest in pharmacological research, particularly in the treatment of resistant infections.

As a chemistry student, one might appreciate the subtle nuances involved in synthesizing such compounds, emphasizing the importance of reaction conditions and protecting groups that could be employed during the synthesis process. The potential impacts of these compounds on health and disease make them worthy of study and innovation!

In addition, understanding the interactions of various atoms within this compound can provide essential insight into optimizing its efficacy, leading to better drug design in the field of medicinal chemistry.

Synonyms
ceftazidime
72558-82-8
Ceftazidime (contains ca. 10% Na2CO3)
78439-06-2
AB02837
SY060164