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Cefotaxime

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Identification
Molecular formula
C16H17N5O7S2
CAS number
63527-52-6
IUPAC name
7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
State
State

Cefotaxime is a solid at room temperature, usually supplied as a powder. In its reconstituted form for injection, it appears as a clear solution.

Melting point (Celsius)
161.00
Melting point (Kelvin)
434.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
455.46g/mol
Molar mass
455.4590g/mol
Density
1.2500g/cm3
Appearence

Cefotaxime typically appears as a white to off-white crystalline powder. It is important to handle with care, ensuring the area is well-ventilated and that personal protective equipment such as gloves and goggles are worn.

Comment on solubility

Solubility of 7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

The solubility of the compound C16H17N5O7S2 is influenced by multiple factors which are crucial to understanding its behavior in various solvents. Here are some key aspects to consider:

  • Polarity: This compound exhibits a complex structure with both polar and non-polar regions which can affect its solubility in different solvents.
  • Hydrogen Bonding: The presence of amine and carboxylic acid functional groups suggests that the compound could engage in hydrogen bonding, enhancing solubility in polar solvents like water.
  • Solvent Type: It is likely to be soluble in alcohols and aqueous solutions due to its polar characteristics, while it may be less soluble in non-polar solvents.

It is essential to note that, as is often the case with complex organic compounds, solubility can also be affected by factors such as:

  1. Temperature
  2. pH of the solution
  3. Presence of other solutes

In summary, while this compound may favor solubility in polar solvents, the overall solubility profile is likely to be a balance of its structural characteristics and external conditions.

Interesting facts

Interesting Facts about 7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

This compound is a fascinating member of a family of molecules known as antibiotics, showcasing a remarkable blend of bioactive properties. Here are some engaging aspects that highlight its significance and unique characteristics:

  • Mechanism of Action: This compound operates by inhibiting bacterial cell wall synthesis, a crucial pathway for bacterial survival and replication. By interfering with this process, it proves effective against a broad spectrum of bacterial infections.
  • Structure-Activity Relationship: The complex structure embodies a bicyclic framework integrated with thiazole and oxo groups, which enhances its binding affinity to bacterial targets, illustrating the intricate relationship between chemical structure and biological function.
  • Therapeutic Implications: Due to its unique structure and mechanism, this compound holds promise in treating resistant bacterial strains, a growing concern in modern medicine. It can be a part of vital therapeutic regimens against infections that are difficult to treat.
  • Research Interest: Scientists are continually exploring derivatives of this compound to improve its efficacy and reduce potential side effects, emphasizing the ongoing hunt for better and safer pharmaceuticals.
  • Multi-Functional Potential: Beyond its antibacterial properties, studies suggest potential anti-inflammatory effects, which adds another layer to its therapeutic potential and utility.

As a chemistry student or a researcher, grasping the complexities of such compounds can deepen your understanding of medicinal chemistry and the intricacies of drug design. As stated in a relevant quote by a leading scientist, “The complexity of nature demands an equally complex understanding of its drugs.” This compound exemplifies how intricate chemical design can lead to significant health advancements.


Synonyms
ceftizoxime
68401-81-0
7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Epocelin
DTXSID60860864
BCP12173
AB02834
SY112007
(6R,7R)-7-[(Z)-2-(2-Imino-2,3-dihydro-4-thiazolyl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
7-[2-(2-Amino-1,3-thiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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