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Ceftezole

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Identification
Molecular formula
C14H13N7O5S2
CAS number
26964-23-8
IUPAC name
7-[[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, ceftezole is in a solid state. Typically stored as a powder, its stability can be affected by external conditions such as light and moisture.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
452.46g/mol
Molar mass
452.4620g/mol
Density
1.7000g/cm3
Appearence

Ceftezole typically appears as a crystalline, white to off-white powder. It is sensitive to moisture and light, and therefore should be stored appropriately to maintain its stability.

Comment on solubility

Solubility of the Compound

The compound 7-[[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (C14H13N7O5S2) exhibits notable solubility characteristics that warrant discussion.

Solubility Insights:

  • Polar and Non-Polar Interactions: The presence of two functional groups—such as the hydroxy phenyl and the carbonyls—promotes polar interactions, which can enhance solubility in polar solvents like water.
  • Impact of the Sulfanyl Group: The sulfanylmethyl moiety may introduce additional solubility features, particularly in organic solvents, due to its ability to stabilize interactions within various solvent environments.
  • Stability in Aqueous Solutions: However, solubility can be affected by factors such as pH and temperature, which can alter the ionization state of the functional groups.
  • Formulation Considerations: In pharmaceutical applications, achieving adequate solubility is crucial for bioavailability, thus formulations may need to include solubilizing agents or co-solvents to optimize the compound's performance.

In summary, this compound's solubility can be enhanced by its polar characteristics and functional groups, yet specific conditions in formulation are essential for successful application. As stated, "A compound's solubility is a key determinant of its utility in biological systems." Understanding these nuances can facilitate effective usage in various chemical contexts.

Interesting facts

Overview of 7-[[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This compound is a fascinating example of a complex organic molecule that demonstrates the intricate nature of chemical design. As a part of the expanding field of medicinal chemistry, compounds like this one are often studied for their potential therapeutic applications.

Key Highlights

  • Structure Complexity: The compound features a bicyclic structure which contributes to its unique properties. Bicyclic compounds are known for their ability to influence biological activity.
  • Therapeutic Potential: The presence of specific functional groups, such as the piperazine and tetrazole moieties, suggests that this compound may exhibit interesting interactions in biological systems, making it a candidate for drug development.
  • Variability: With multiple substituents, including a hydroxyphenyl group and a carbonyl group, the potential for diverse chemical reactivity is substantial. This may allow for modifications that enhance its selectivity and efficacy.
  • Research Implications: Compounds with such structural features are often the focus of research aimed at understanding their mechanism of action in biological environments, especially in targeting specific enzymes or receptors.

In the words of famous chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound stands as a reminder of the potential that innovative chemical design holds in contributing to advancements in medical science.

Conclusion

7-[[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate reflects the ingenuity of drug design and the promise it holds for future pharmacological advancements. Its complexity is not merely a challenge but an opportunity for scientists to explore new therapeutic avenues.

Synonyms
7-{[{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
HMS657E09
STK084799
AKOS001678409
AKOS022084175
NCGC00159444-03
NCGC00159444-04
NCGC00159444-05
AN-329/40887286
7-{[{[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetraazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate