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Ceftriaxone

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Identification
Molecular formula
C18H18N8O7S3
CAS number
73384-59-5
IUPAC name
7-[[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino-acetyl]amino]-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

Solid: Ceftriaxone is typically in a solid state at room temperature.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.00
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.00
General information
Molecular weight
554.58g/mol
Molar mass
554.5790g/mol
Density
1.3640g/cm3
Appearence

Ceftriaxone is a white to yellowish crystalline powder. It is hygroscopic and slightly soluble in water, very slightly soluble in ethanol.

Comment on solubility

Solubility of the Compound

The solubility of the compound 7-[[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino-acetyl]amino]-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, represented by the formula C18H18N8O7S3, can be complex due to its intricate structure and various functional groups. Several factors influence its solubility, including:

  • Polarity: The presence of polar groups (such as –OH, –NH2) can enhance solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents is crucial. Compounds with multiple amino groups are likely to exhibit increased solubility.
  • Ionic Interactions: The imidazopyridazine group can impart ionic characteristics, influencing solubility in aqueous environments.

In practical terms, it is essential to recognize that solubility may vary dramatically based on factors such as pH, temperature, and the presence of other ions in solution. For example, compounds like this one, which contain both acidic and basic functional groups, can have their solubility altered significantly in different pH conditions.

In conclusion, while a direct measure of solubility in various solvents would provide more clarity, the inherent structure of this compound suggests potential for moderate solubility in polar solvents, while also indicating that its behavior may vary considerably under different chemical environments.

Interesting facts

Interesting Facts about 7-[[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino-acetyl]amino]-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This fascinating compound belongs to a class of molecules with significant *biological activity*, showcasing the intricate relationship between *chemical structure* and *pharmacological function*. Here are some key highlights:

  • Multifaceted Applications: Due to its complex structure, it has potential applications in the pharmaceutical industry, specifically in the development of antibiotics or anticancer agents.
  • Diverse Functional Groups: The presence of multiple functional groups, like the thiadiazole and imidazo[1,2-b]pyridazine moieties, allows for *interactions with various biological targets*, enhancing its efficacy and potency.
  • Synthetic Challenges: Synthesis of this compound can be quite challenging, requiring advanced techniques in organic chemistry. This demonstrates the intricate design necessary to achieve such *specificity and selectivity* in medicinal chemistry.
  • Research Potential: It is a prime candidate for further research due to its *unique structural composition*, which could lead to insights into new treatments for diseases that are currently difficult to manage.

As scientists continue to explore the depths of organic and medicinal chemistry, compounds like this serve as a reminder of the *limitless possibilities* that lie within molecular design. Understanding the intricate details of such compounds not only enhances our *chemical knowledge* but also drives forward the boundaries of *medical science*.

Synonyms
Cefozopran
113359-04-9
(-)-1-{[(6R,7R)-7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1H-imidazo[1,2-b]pyridazin-4-ium
(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
BCP22806
DB-041167
SCE-2787; SCE2787; SCE 2787