Cefotaxime | Solubility of Things

Identification

Molecular formula

C₁₆H₁₇N₅O₇S₂

CAS number

63527-52-6

IUPAC name

7-[(2-formyloxy-2-phenyl-acetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

State

At room temperature, cefotaxime is in a solid state and typically provided as a crystalline powder that is intended for reconstitution.

Melting point (Celsius)

158.00

Melting point (Kelvin)

431.00

Boiling point (Celsius)

350.00

Boiling point (Kelvin)

623.15

General information

Molecular weight

455.46g/mol

Molar mass

455.4600g/mol

Density

1.6300g/cm³

Appearence

Cefotaxime typically appears as a white to creamy white crystalline powder. It is often provided in a lyophilized form for injection, appearing as a white to off-white powder in vials, which needs to be reconstituted with a solvent before use.

Comment on solubility

Solubility Characteristics of 7-[(2-formyloxy-2-phenyl-acetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility of the compound C₁₆H₁₇N₅O₇S₂ in various solvents is a key factor for its potential applications. The solubility may be influenced by:

Molecular Structure: The presence of functional groups such as the carboxylate and formyl can enhance solubility in polar solvents.
Polarity: The overall polarity of the compound plays a significant role; polar solvents such as water may dissolve this compound better than non-polar solvents.
Temperature: Solubility can often increase with temperature, making it essential to consider thermal conditions during synthesis or application.
pH Sensitivity: Given the presence of a carboxylic acid functional group, solubility may vary with changes in pH, possibly enhancing solubility in alkaline conditions.

It is essential to note that solubility data is critical for drug formulation and delivery systems since:

Aqueous solubility determines the bioavailability of the compound.
Low solubility may present challenges in achieving therapeutic effects.

In summary, understanding the solubility of this compound will enable researchers and developers to effectively utilize its properties, guiding further experimental studies and application strategies.

Interesting facts

Interesting Facts about the Compound: 7-[(2-formyloxy-2-phenyl-acetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This complex compound is a fascinating example of modern medicinal chemistry, showcasing the intricate designs chemists can create. With its myriad functional groups and structural features, it has potential implications in pharmaceutical research. Here are some intriguing aspects of this compound:

Unique Structure: The compound contains a bicyclic structure, specifically the 1-azabicyclo[4.2.0]oct core, which is rare and contributes to unique chemical properties.
Bioactive Potential: The presence of a tetrazole ring, which is a common motif in drug design, suggests this compound may interact effectively with biological systems, potentially leading to new therapeutic applications.
Multifunctional Groups: The multi-faceted design integrates various functionalities, such as formyloxy, sulfanyl, and carboxylate groups, which may enhance solubility and binding capabilities in biological environments.
Synthetic Challenges: Creating such a compound involves intricate synthetic pathways and techniques, highlighting the advanced skills required in the field of organic synthesis.
Potential Research Avenues: Given its structural complexity, researchers can explore a range of studies, from elucidating its mechanism of action to testing its efficacy and safety in various biological assays.

As a testament to the creativity in drug design, this compound exemplifies how chemical diversity can lead to potential breakthroughs in therapeutics. It opens doors for innovative research, fostering collaboration among chemists, biologists, and pharmacologists.

Synonyms

NCGC00178718-01

AB00053626_02