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Cefamandole

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Identification
Molecular formula
C16H16N6O5S2
CAS number
34444-01-4
IUPAC name
7-[(2-hydroxy-2-phenyl-acetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, cefamandole is typically found as a solid due to its crystalline form. It is stable when stored properly in its powdered form, but as an antibiotic, it is often converted into a soluble form for medical administration.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
90.00
Boiling point (Kelvin)
363.15
General information
Molecular weight
490.51g/mol
Molar mass
490.5050g/mol
Density
1.4172g/cm3
Appearence

Cefamandole typically appears as a white to off-white crystalline powder. It is a beta-lactam antibiotic and its crystalline nature gives it a solid form that is generally stable under recommended storage conditions. However, its appearance can vary slightly if formulated as a salt or within different pharmaceutical preparations.

Comment on solubility

Solubility of C16H16N6O5S2

The solubility of the compound 7-[(2-hydroxy-2-phenyl-acetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate can be characterized by the following points:

  • Polarity: This compound contains both polar functional groups, such as hydroxyl and carboxyl, as well as nonpolar regions. The presence of these groups often leads to increased solubility in polar solvents, such as water.
  • Interactions: Hydrogen bonding potential due to the hydroxyl group and carboxylate group can enhance solubility. Additionally, the sulfanyl group may interact favorably with solvent molecules, further contributing to solvation.
  • Electrostatic Effects: The amino and carboxyl groups can carry partial charges, which may improve solubility in ionic or polar environments.
  • Concentration Dependence: Solubility may vary with concentration; in higher concentrations, solubility may decrease due to potential precipitation or changes in molecular interactions.

It is essential to consider the specific solvent conditions when evaluating the solubility of this compound. In general, compounds with complex structures like this one tend to exhibit unique solubility profiles influenced by their chemical structure and the environment in which they are placed.

Interesting facts

Interesting Facts about 7-[(2-hydroxy-2-phenyl-acetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This compound is a fascinating example of modern medicinal chemistry, showcasing the intricate designs chemists use to create molecules with potential therapeutic effects. Here are some compelling aspects:

  • Multifunctional Potential: The structure features multiple functional groups, suggesting it may possess diverse biological activities. This characteristic makes it a candidate for various pharmacological applications.
  • Unique Bicyclic Structure: The presence of a bicyclic framework contributes to its stability and may enhance interactions with biological targets, which is critical for drug activity.
  • Incorporation of Sulfur: The sulfonyl group embedded within the structure is vital for its reactivity and can play a role in the mechanism of action in biological systems.
  • Use of Tetrazole Moiety: The tetrazole ring is known for its bioisosteric properties, often replacing carboxylic acids to enhance drug solubility and absorption.

In exploring the compound, one can appreciate how medicinal chemists meticulously design molecules, emphasizing the importance of each element in achieving desired biological efficacy. As noted by chemist Robert H. Grubbs, "The beauty of a molecule lies not just in its aesthetic structure, but in its ability to interact and produce profound effects." This compound exemplifies that philosophy, making it an exciting subject for further research.

Overall, the complexity and potential applications of this compound highlight the innovative spirit of contemporary chemistry, focused on improving human health through targeted molecular design.

Synonyms
NCGC00178290-01
AB00053623_02