Curcumin | Solubility of Things

Identification

Molecular formula

C₂₁H₂₀O₆

CAS number

458-37-7

IUPAC name

7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid

State

At room temperature, curcumin is typically a solid in a crystalline form. It is generally stable under normal conditions but degrades when exposed to excessive light or air for prolonged periods.

Melting point (Celsius)

183.00

Melting point (Kelvin)

456.00

Boiling point (Celsius)

356.00

Boiling point (Kelvin)

629.00

General information

Molecular weight

368.39g/mol

Molar mass

368.3850g/mol

Density

1.2000g/cm³

Appearence

Curcumin is a bright yellow compound that is commonly found as a crystalline powder. It can also appear as an orange-yellow solid when pure. The color arises due to its extended conjugated systems of double bonds which are responsible for its vibrant hue.

Comment on solubility

Solubility of 7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid

The solubility of 7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid (C₂₁H₂₀O₆) can be influenced by a variety of factors due to its complex molecular structure.

Factors Affecting Solubility

Polarity: The presence of hydroxamic acid functional groups often results in enhanced solubility in polar solvents like water, due to hydrogen bonding.
Organic Solvents: Conversely, the hydrophobic parts of the molecule suggest that it could exhibit better solubility in non-polar organic solvents such as ethanol or dichloromethane.
Concentration: Higher concentrations may lead to partial solubility limitations, particularly in less polar solvents.

In conclusion, the solubility profile of this compound illustrates the intricate balance of its polar and non-polar characteristics. It is likely to be:

Moderately soluble in water due to hydrogen bonding potential.
More soluble in organic solvents, enhancing its utility in various chemical applications.

Understanding these solubility characteristics is key when considering the practical applications and formulations involving this compound.

Interesting facts

Interesting Facts about 7-[4-(Dimethylamino)phenyl]-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic Acid

The compound 7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid is a fascinating member of the hydroxamic acid family, known for its diverse biological properties and potential applications in various fields, particularly in medicinal chemistry. Here are some intriguing aspects of this compound:

Biological Significance: Hydroxamic acids are known for their role as inhibitors of metalloproteinases, which are crucial in various physiological processes, including tissue remodeling and cell signaling.
Structure-Activity Relationship: The unique structure of this compound, containing a dimethylamino group and multiple double bonds, suggests a rich potential for reactivity and interaction with biological targets.
Versatile Applications: Due to its ability to chelate metal ions, this compound may find applications in:
- Pharmaceuticals - as a drug candidate in cancer therapies.
- Agriculture - offering potential use as a biopesticide.
- Biochemical assays - serving as a tool for studying enzyme activities.
Research Interest: Ongoing studies probe its efficacy and safety profiles, contributing to a deeper understanding of its mechanism of action and potential therapeutic uses.

Overall, the complex structure and promising biological activity of 7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid make it a compound of great interest within the scientific community. As research continues, we may uncover even more exciting applications and insights related to this compound.

Synonyms

7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Tricostatin A

Trichostatin A (racemate)

DTXSID30860735

HMS3654C11

SB17023

NCI60_038563

Q27163404

7-[4-(dimethylamino) phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide