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Nafadolone

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Identification
Molecular formula
C25H29NO3
CAS number
74836-66-5
IUPAC name
7-(4,5-dimethoxy-2-methyl-1-naphthyl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol
State
State
Nafadolone is in a solid state at room temperature. It is commonly handled in a laboratory setting as a fine powder, which allows for easy measurement and mixing with solvents or other solid compounds for experimental purposes.
Melting point (Celsius)
188.30
Melting point (Kelvin)
461.50
Boiling point (Celsius)
526.20
Boiling point (Kelvin)
799.30
General information
Molecular weight
393.50g/mol
Molar mass
393.4950g/mol
Density
1.2485g/cm3
Appearence

Nafadolone is typically found as a crystalline solid when isolated in pure form. It may appear as a powder with a white to off-white color. The compound's fine crystalline nature can contribute to a glossy texture when it is compacted, but generally, it remains as a powdery substance in most laboratory conditions.

Comment on solubility

Solubility of 7-(4,5-Dimethoxy-2-methyl-1-naphthyl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol

This compound, with its intricate structure, showcases interesting solubility properties primarily influenced by its functional groups and overall molecular configuration. Here are some key points about its solubility:

  • Polar vs. Non-Polar: The presence of an -OH (hydroxyl) group in the structure makes the compound somewhat polar, which can enhance its solubility in polar solvents, such as water and methanol.
  • Aromatic Hydrocarbons: The naphthalene moiety may introduce hydrophobic characteristics, which often lead to increased solubility in non-polar organic solvents like chloroform or ethyl acetate.
  • Solvophobic Effect: Given the bulky naphthyl group and dimethoxy substituents, solubility might be reduced in extremely polar solvents due to steric hindrance and reduced interactions.
  • Temperature Influence: Solubility is often temperature-dependent. As temperature increases, solubility generally increases as well, particularly for solid compounds when dissolved in a liquid.

When considering the solubility of this compound, it is essential to conduct experimental evaluations in various solvents to determine the optimal conditions for dissolution. This is especially important for compounds utilized in pharmaceutical formulations where solubility can significantly impact bioavailability and efficacy.

Interesting facts

Interesting Facts about 7-(4,5-Dimethoxy-2-methyl-1-naphthyl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol

This compound, known for its complex structure, belongs to a class of chemical compounds called isoquinolines. Isoquinolines are significant in medicinal chemistry due to their diverse biological activities. Here are some notably intriguing aspects of this compound:

  • Biological Activity: Compounds in the isoquinoline family often exhibit a variety of pharmacological properties, including antimicrobial, anticancer, and neuroprotective effects. This makes them prominent candidates for drug discovery and development.
  • Structure-Activity Relationship: The presence of methoxy groups in the naphthalene moiety can substantially influence the compound's activity and solubility, highlighting the importance of structural nuances in medicinal chemistry.
  • Synthesis Challenges: The synthesis of such complex structures often involves intricate multi-step processes, requiring advanced techniques in organic synthesis. This presents a fascinating challenge for chemists aiming to create and refine these compounds.
  • Application in Research: Due to its unique structure, researchers may study this compound to explore new pharmacological mechanisms or to develop derivatives with enhanced therapeutic profiles.
  • Potential in Neurological Studies: The incorporation of the tetrahydroisoquinoline structure is particularly interesting, as compounds in this category have been researched for their effects on the central nervous system, providing potential avenues for treating neurological disorders.

The intricate design of 7-(4,5-dimethoxy-2-methyl-1-naphthyl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol not only showcases the creativity involved in organic chemistry but also emphasizes the ongoing search for effective therapeutic agents. As one researcher put it, “Understanding the synergy of structure and function in complex compounds is the key to unlocking new medicinal opportunities.”

As a result, this compound serves not merely as a chemical entity but as a beacon of potential in both academic research and practical applications within pharmacology.

Synonyms
Dioncophyllin A
MXIZZLBQRBAZEX-UHFFFAOYSA-N
8-Isoquinolinol, 7-(4,5-dimethoxy-2-methyl-1-naphthalenyl)-1,2,3,4-tetrahydro-1,3-dimethyl-, (1R,3R,7S)-
8-Isoquinolinol, 7-(4,5-dimethoxy-2-methyl-1-naphthalenyl)-1,2,3,4-tetrahydro-1,3-dimethyl-, stereoisomer
7-(4,5-Dimethoxy-2-methyl-1-naphthyl)-1,3-dimethyl-1,2,3,4-tetrahydro-8-isoquinolinol #