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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
State
State

At room temperature, noscapine is in a solid state.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
358.00
Boiling point (Kelvin)
631.15
General information
Molecular weight
413.45g/mol
Molar mass
413.4520g/mol
Density
1.4600g/cm3
Appearence

Noscapine appears as a white or slightly off-white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

The solubility of the compound 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one is influenced by several factors, contributing to its potential applications in various fields such as pharmaceuticals and materials science. Key aspects of its solubility include:

  • Polarity: The presence of amino and hydroxyl functional groups enhances the polarity of the compound, thus suggesting a greater likelihood of solubility in polar solvents.
  • Hydrogen bonding: The ability to form hydrogen bonds with solvent molecules can significantly affect solubility, potentially increasing its dissolution in water.
  • Saturation point: Depending on the concentration, the saturation point can vary, essential for understanding the compound's behavior in different solutions.
  • Application environment: Solubility is context-dependent; in biological environments, for example, solubility might be improved in physiological conditions compared to organic solvents.

In summary, while the structural features of 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one may grant it enhanced solubility in polar conditions, further experimental studies are necessary to delineate its solubility characteristics across various solvents. Such insights could vastly improve its practical applications.

Interesting facts

Interesting Facts about 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

This intriguing compound, often referred to in shorthand within scientific circles, showcases a fascinating array of functional groups and structural features that merit discussion. Originally derived from complex organic synthesis, this molecule is of interest for its potential biological activities and applications in medicinal chemistry.

Key Features:

  • Amino Group: The presence of the amino group indicates potential for hydrogen bonding, which can enhance interactions within biological systems.
  • Hydroxy Group: The hydroxyl functionality not only increases solubility in biological mediums but also provides sites for further chemical modifications.
  • Trimethoxy Substituents: These methoxy groups can influence the electron-donating properties of the molecule, potentially affecting its reactivity and biological activity.
  • Unique Ring Structure: The benzo[a]heptalene backbone offers a unique aromatic system that may exhibit distinct electronic properties compared to typical benzene derivatives.

In the realm of medicinal chemistry, compounds like this are often investigated for their therapeutic potential. Research has noted that similar structures display a range of biological activities, including:

  • Antioxidant properties
  • Anti-inflammatory effects
  • Potential anticancer activity

Furthermore, the compound's ability to interact with various biological targets could pave the way for innovative drug design approaches. As a scientist or chemistry student, one must also consider:

  • How altering different functional groups might affect the compound's efficacy and safety profile.
  • The potential for this compound to serve as a scaffold for synthesizing analogs with enhanced biological activity.

In summary, 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one stands as a testament to the intricate relationship between molecular structure and biological function, inviting further exploration and study in the world of chemical synthesis and pharmacology.

Synonyms
Deacetylcolchiceine
(R/S)-N-Deacetyl Colchiceine
68296-64-0
7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
Prestwick_353
Prestwick0_000580
Prestwick1_000580
Prestwick2_000580
Desacetylcolchiceine; N-Deacetylcolchiceine; NSC 36796
Oprea1_221824
SPBio_002619
SCHEMBL1822222
CHEMBL3729937
CHEBI:95161
HMS1569D22
CCG-231728
WLN: L B677 MV&T&J CO1 DO1 EO1 JZ NQ
Q27166959
Benzo[a]heptalen-9(5H)-one,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (S)-