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Methylene blue

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Identification
Molecular formula
C16H18ClN3S
CAS number
7220-79-3
IUPAC name
(7-aminophenothiazin-3-ylidene)-dimethyl-ammonium;chloride
State
State

At room temperature, methylene blue is typically in the form of a solid powder. It is stable under normal conditions.

Melting point (Celsius)
100.00
Melting point (Kelvin)
373.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
319.85g/mol
Molar mass
373.9000g/mol
Density
1.0000g/cm3
Appearence

Methylene blue appears as a dark green crystalline powder. It readily forms a deep blue solution when dissolved in water. The intense color of its aqueous solution is one of its most distinct features.

Comment on solubility

Solubility of (7-aminophenothiazin-3-ylidene)-dimethyl-ammonium;chloride

The solubility characteristics of the compound (7-aminophenothiazin-3-ylidene)-dimethyl-ammonium;chloride can be intriguing, primarily due to its complex structure and ionic nature. This compound is likely to exhibit the following solubility behaviors:

  • Solubility in Water: As an ammonium salt, it is generally expected to be soluble in water due to the ionic interactions that favor solvation.
  • Solvent Dependence: Its solubility may vary significantly in non-polar solvents; compounds like these often have limited solubility or may not dissolve at all.
  • Temperature Influence: Increased temperature may enhance solubility, allowing more of the compound to dissolve in water.

It's essential to note that the presence of functional groups such as the –NH₂ (amino) group can contribute to the solubility by forming hydrogen bonds with water molecules, whereas the phenothiazine moiety could introduce hydrophobic characteristics that might limit solubility in some solvents.

In summary, the solubility of (7-aminophenothiazin-3-ylidene)-dimethyl-ammonium;chloride is influenced by:

  1. The ionic form and its ability to interact with water
  2. The nature of the solvent used
  3. The temperature of the solution

Understanding the solubility of such compounds is vital as they often play crucial roles in pharmaceutical applications, chemical synthesis, and biological interactions.

Interesting facts

Interesting Facts about (7-aminophenothiazin-3-ylidene)-dimethyl-ammonium;chloride

(7-aminophenothiazin-3-ylidene)-dimethyl-ammonium;chloride is a fascinating compound with a rich intersection of chemistry and medicinal applications. Here are some interesting insights:

  • Diverse Applications: This compound belongs to the class of phenothiazine derivatives, which are well-known for their broad spectrum of biological activities. Many phenothiazines have been used traditionally in treating psychiatric disorders and as antipsychotic medications.
  • Structure and Function: The structure features a phenothiazine moiety, which is a tricyclic compound with notable properties. The presence of an amino group enhances its reactivity and interaction with various biological targets.
  • Potential in Research: Researchers are actively investigating similar compounds for their potential as dyes, antibacterial agents, or even as tools in the field of molecular imaging. The ability to modify these compounds opens doors to numerous synthetic pathways.
  • Mechanism of Action: Many compounds in this category exhibit their effects through dopaminergic and adrenergic pathways in the brain, impacting neurotransmission. Understanding these mechanisms can lead to innovations in pharmacology.
  • Stability and Storage: As with many ammonium salts, handling and storage considerations are critical due to hygroscopic traits. Proper laboratory practice is required to ensure integrity and effectiveness.

In summary, (7-aminophenothiazin-3-ylidene)-dimethyl-ammonium;chloride serves as an excellent example of how chemistry can bridge the gap between basic science and practical medicine, offering insights that could spur further research and application in various fields.

Synonyms
AZURE A
Giemsa stain
531-53-3
51811-82-6
Giemsa's stain
Azure A chloride
Dimethylthionine
Azur A
N,N-Dimethylthionine
3-Amino-7-(dimethylamino)phenothiazin-5-ium chloride
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride
C.I. 52005
Azure A eosinate
asym-Dimethyl-3,7-diaminophenazathionium chloride
3-Amino-7-dimethylaminophenothiazin-5-ium chloride
3-Amino-7-dimethylaminophenazathionium chloride
Azure A (chloride)
CHEBI:87637
MFCD00012112
CI-52005
(7-aminophenothiazin-3-ylidene)-dimethylazanium;chloride
CHEMBL3330735
M731V243EF
NSC-326661
Azure A (Technical Grade)
62298-43-5
Methylene Azure A
7-AMINO-N,N-DIMETHYL-3H-PHENOTHIAZIN-3-IMINIUM CHLORIDE
EINECS 208-510-7
NSC 326661
Azuresin
Sinitest
giemsa-stain
UNII-M731V243EF
CCRIS 9315
Diagnex Blue
Mancha Giemsa
Macchia di Giemsa
Tincion de Giemsa
Teinture de Giemsa
EINECS 257-438-2
Azuresin [BAN:NF]
N,N- Dimethylthionine
Fast Giemsa Stain Kit
AZURE A [MI]
SCHEMBL137066
7-amino-N,N-dimethylphenothiazin-3-iminium chloride
Azure A chloride salt;CI 525
CHEMBL1091115
DTXSID2040157
AZURE A CARBACRYLIC RESIN
METHYLENE BLUE IMPURITY B
PGWTYMLATMNCCZ-UHFFFAOYSA-M
3-Amino-7-(dimethylamino)phenothiazin-5-ium chloride (1:1)
Azure A (C.I. 52005)
HY-D0944
HY-D0947
EINECS 263-491-2
BDBM50055937
NSC326661
AKOS015916263
AKOS024306943
AKOS024356709
FA52728
FG01512
NSC 374111
Azure A chloride, Dye content >=70 %
DA-61459
DA-61460
DA-71257
MS-24168
CS-0022121
CS-0022125
NS00042981
F72133
G73505
Q4833095
7-(DIMETHYLAMINO)PHENOTHIAZIN-3-IMINIUM CHLORIDE
3-AMINO-7-(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM CHORIDE
Azure A chloride, certified by the Biological Stain Commission
METHYLTHIONINIUM CHLORIDE HYDRATE IMPURITY B [EP IMPURITY]
n-(7-amino-3h-phenothiazin-3-ylidene)-n-methylmethanaminium chloride
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride (1:1)
Azure A chloride, certified by the Biological Stain Commission, Dye content 70 %
143629-25-8
3-Amino-7-(dimethylamino)phenothiazin-5-ium, salt with 2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one (2:1)
8050-34-8