Interesting facts
Interesting Facts about 7-[bis(2-chloroethyl)amino]-1H-indole-2-carboxylic acid
7-[bis(2-chloroethyl)amino]-1H-indole-2-carboxylic acid, often referred to in chemical research circles by its structural attributes, is a fascinating compound due to its biological significance and potential therapeutic uses. It falls under the category of antineoplastic agents, which are compounds that inhibit or prevent the growth of tumors. Here are some intriguing points about this compound:
- Mechanism of Action: The compound contains a bis(2-chloroethyl)amino functionality, which is known to produce alkylating agents upon metabolic activation. These agents can form covalent bonds with nucleophilic sites in DNA, leading to disruption of cellular replication and ultimately apoptosis (programmed cell death).
- Use in Cancer Therapy: Due to its alkylating properties, it has been investigated for its effectiveness against various types of cancer cells. Compounds of this nature can be pivotal in chemotherapy regimens, especially for cancers that are resistant to other forms of treatment.
- Structure-Activity Relationship (SAR): The indole core structure is of great interest in medicinal chemistry, as it can enhance the selectivity and potency of compounds. Understanding how modifications to its structure affect biological activity can lead to the development of more effective medicinal agents.
- Toxicity Profile: Like many chemotherapeutic agents, this compound may possess a range of side effects. Researching and minimizing toxicity while maximizing therapeutic effects remains a primary focus in drug development.
- Future Research Directions: Ongoing studies aim to explore novel derivatives of 7-[bis(2-chloroethyl)amino]-1H-indole-2-carboxylic acid to improve efficacy, reduce toxicity, and overcome drug resistance in cancer treatments. The quest for an ideal chemotherapeutic agent is relentless, and this compound is part of that journey.
In summary, 7-[bis(2-chloroethyl)amino]-1H-indole-2-carboxylic acid is more than just a chemical formula; it embodies hope in the ongoing battle against cancer, demonstrating how the intricate dance of molecules can have profound implications for human health.
Synonyms
731-76-0
AT-267
BRN 0420083
INDOLE-2-CARBOXYLIC ACID, 7-(BIS(2-CHLOROETHYL)AMINO)-
7-(Bis(2-chloroethyl)amino)-indole-2-carboxylic acid
DTXSID40223372
DTXCID40145863
7-[bis(2-chloroethyl)amino]-1H-indole-2-carboxylic acid
Solubility of 7-[bis(2-chloroethyl)amino]-1H-indole-2-carboxylic acid
The solubility of 7-[bis(2-chloroethyl)amino]-1H-indole-2-carboxylic acid can be characterized by several important factors:
In summary, while the compound may exhibit reasonable solubility in *polar solvents* such as methanol or DMSO, one must consider the balance between its polar functional groups and the hydrophobic nature imparted by the chlorinated segments. Thus, the precise solubility can vary significantly depending on the solvent used, and an empirical approach is often necessary to determine the actual solubility profile.