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Brotizolam

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Identification
Molecular formula
C15H15BrN4O
CAS number
57801-81-7
IUPAC name
7-bromo-1-[2-(diethylamino)ethyl]-5-(2-pyridyl)-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, Brotizolam is typically in a solid state.

Melting point (Celsius)
237.00
Melting point (Kelvin)
510.15
Boiling point (Celsius)
445.70
Boiling point (Kelvin)
718.85
General information
Molecular weight
344.21g/mol
Molar mass
344.2300g/mol
Density
1.4300g/cm3
Appearence

Brotizolam is a white to off-white crystalline powder.

Comment on solubility

Solubility of 7-bromo-1-[2-(diethylamino)ethyl]-5-(2-pyridyl)-3H-1,4-benzodiazepin-2-one

The solubility of 7-bromo-1-[2-(diethylamino)ethyl]-5-(2-pyridyl)-3H-1,4-benzodiazepin-2-one is a crucial factor in its potential applications and effectiveness. Understanding its solubility characteristics can provide insights into its behavior in different environments.

Key points regarding the solubility of this compound include:

  • Polar Solvents: The presence of the diethylamino group may enhance solubility in polar solvents due to hydrogen bonding capabilities.
  • Non-Polar Solvents: The aromatic structures within the compound may promote moderate solubility in non-polar solvents.
  • pH Influence: The solubility can be affected by the pH of the solution, potentially increasing in acidic conditions where protonation can occur.
  • Temperature Effects: Increased temperature generally enhances solubility; however, the specific impact may vary depending on the solvent.

Overall, while the precise solubility data for this specific compound might not be extensively documented, the presence of various functional groups suggests a complex interaction with different solvents.
Understanding these solubility dynamics is essential for formulation and pharmaceutical development, as they influence the compound's bioavailability and efficacy.

Interesting facts

Interesting Facts about 7-bromo-1-[2-(diethylamino)ethyl]-5-(2-pyridyl)-3H-1,4-benzodiazepin-2-one

This compound belongs to a class of chemicals known as benzodiazepines, which are widely recognized for their sedative and anxiolytic properties. Here are some fascinating aspects:

  • Medicinal Applications: Benzodiazepines are often prescribed for anxiety, insomnia, and other conditions affecting mental health. Researchers study compounds like this one to understand their potential as therapeutic agents.
  • Complex Structure: The presence of a bromine atom in this structure, along with a pyridine ring, contributes to its unique reactivity and can influence its biological activity, making it a topic of interest for synthetic chemists.
  • Diethylamino Group: The diethylamino group enhances the lipophilicity of the compound, impacting its absorption and distribution in biological systems.

As a result of their diverse mechanisms of action, compounds such as this one are regularly researched in the fields of pharmacology and medicinal chemistry. Researchers often say, "Understanding the structure-activity relationship in benzodiazepines is crucial for developing safer and more effective medications."

Moreover, this compound exemplifies how small changes in molecular structure can lead to significant variations in pharmacological properties, reiterating the importance of detailed structural analysis in drug design.