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Diazepam

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Identification
Molecular formula
C16H13ClFN2O
CAS number
439-14-5
IUPAC name
7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one
State
State
Diazepam is typically a solid at room temperature, presenting in crystalline or powder form.
Melting point (Celsius)
131.00
Melting point (Kelvin)
404.00
Boiling point (Celsius)
391.50
Boiling point (Kelvin)
664.70
General information
Molecular weight
284.75g/mol
Molar mass
284.7430g/mol
Density
1.3060g/cm3
Appearence

Diazepam typically appears as colorless to light yellow crystals. It can also manifest as a white to light yellow powder. This compound is practically odorless.

Comment on solubility

Solubility of 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one

The solubility behavior of 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one is a critical parameter, especially in the context of pharmaceutical applications. Understanding its solubility can influence drug formulation and delivery. Here’s a closer look at the factors affecting its solubility:

  • Polarity: The presence of both hydrophilic (diethylamino group) and hydrophobic components (fluorophenyl moiety) suggests that solubility may vary widely in different environments.
  • pH Dependence: The solubility of functional groups such as the benzodiazepinone structure can be significantly affected by the pH of the solution, potentially leading to better solubility in either acidic or basic conditions.
  • Solvent Interaction: Solubility can be enhanced in organic solvents, which may better accommodate the compound’s structural characteristics, particularly due to its large size and complex structure.
  • Formulation Strategy: Using surfactants or co-solvents in formulations may improve solubility, which is essential for effective biological absorption.

In summary, the solubility of this compound is governed by its chemical structure and the environment in which it is located. It could present challenges for solubility, but with the right conditions and formulations, it can be optimized for various applications.

Interesting facts

Interesting Facts about 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine class, which is widely known for its use in medicine, particularly as anxiolytics, sedatives, and hypnotics. The benzodiazepine family combines a benzene ring and a diazepine structure, leading to unique pharmacological properties.

Key Characteristics

  • Pharmacological Action: Benzodiazepines act on the central nervous system by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA), which results in a calming effect.
  • Potential Applications: Due to its chemical structure, this compound may exhibit strong anxiolytic properties, making it a candidate for treating anxiety disorders.
  • Research Interest: With the addition of a fluorophenyl group and diethylamino side chain, this compound may have altered bioavailability and pharmacokinetics, warranting further research.

As scientists delve into the diverse realms of medicinal chemistry, compounds such as this one illustrate the importance of molecular modification. "The road to drug discovery is paved with compounds that exhibit potential; each modification can lead to different therapeutic outcomes," reflects a common sentiment in the field.

Challenges and Considerations

  • Side Effects: While benzodiazepines are effective, they can also lead to dependence, tolerance, and various side effects, which is crucial to consider in drug development.
  • Drug Interaction: Knowledge of how this compound interacts with other drugs is essential for ensuring patient safety and effective therapy.

In summary, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one exemplifies the intricate dance of chemistry and pharmacology, where small changes in molecular structure yield significant differences in activity and safety profile. This compound's unique chemical characteristics make it an exciting subject of study in the ongoing search for effective therapeutic agents in anxiety management.