Diazepam | Solubility of Things

Identification

Molecular formula

C₁₆H₁₃ClN₂O

CAS number

439-14-5

IUPAC name

7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one

State

Diazepam is typically encountered in a solid state at room temperature. It is commonly formulated into tablets or capsules for pharmaceutical applications.

Melting point (Celsius)

131.00

Melting point (Kelvin)

404.15

Boiling point (Celsius)

336.00

Boiling point (Kelvin)

609.15

General information

Molecular weight

284.75g/mol

Molar mass

284.7050g/mol

Density

1.3060g/cm³

Appearence

Diazepam is a white to light yellow crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one can be categorized based on various solvents and conditions. Here are some key points to consider:

Organic Solvents: This compound generally exhibits good solubility in organic solvents such as DMSO (dimethyl sulfoxide) and ethanol, which are often utilized in medicinal chemistry.
Aqueous Solubility: Its solubility in water is typically low, which can limit its application in aqueous formulations.
pH Dependence: The solubility behavior might also be influenced by the pH of the solution, indicating potential interactions with acidic or basic environments.
Temperature Effects: Increasing temperature often enhances solubility, making it crucial to consider temperature-controlled conditions during experiments.
Stability Concerns: Certain solvents can also affect the stability of the compound, leading to degradation in non-ideal conditions.

Overall, understanding the solubility of this compound is essential for its effective use in pharmaceuticals and chemical applications, as it not only affects absorption but also influences formulation strategies. As the saying goes, “Solubility is key!”

Interesting facts

Interesting Facts about 7-Chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one

The compound 7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one belongs to the benzodiazepine class of medications, which are widely recognized for their *sedative* and *anxiolytic* effects. Here are some fascinating aspects to consider:

Benzodiazepine Background: This compound is part of a large family of psychoactive drugs that act on the central nervous system. Benzodiazepines are often prescribed for anxiety, insomnia, and various other conditions.
Chlorine Substituent: The presence of chlorine at the 7-position is significant; it often enhances the compound's efficacy and modifies its pharmacokinetic properties.
Dimethylamino Group: The dimethylamino moiety can contribute to increased lipophilicity, allowing better penetration through biological membranes and potentially more pronounced effects.
Research Applications: Compounds like this one are valuable in research for their role in studying neurotransmitter systems, particularly gamma-aminobutyric acid (GABA) receptors, affording insights into various neurological disorders.
Historical Context: The discovery and development of benzodiazepines date back to the 1950s, marking a significant shift in the treatment of mental health conditions and opening the door for the development of newer compounds with specific therapeutic targets.

In conclusion, 7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one serves as an intriguing example of how modifications in chemical structure can lead to novel therapeutic agents with diverse functions. As a chemist or a student, exploring these compounds can reveal the intricate dance between chemical structure and biological action.