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Lorazepam

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Identification
Molecular formula
C15H10ClN2O
CAS number
846-49-1
IUPAC name
7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one;dihydrochloride
State
State

At room temperature, Lorazepam is typically in a solid state. It is often provided in tablet form for medicinal use.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
196.00
Boiling point (Kelvin)
469.15
General information
Molecular weight
321.16g/mol
Molar mass
321.1610g/mol
Density
1.2000g/cm3
Appearence

The compound appears as a white to yellowish crystalline powder. It may have a faint characteristic odor, which is typical of many benzodiazepine derivatives.

Comment on solubility

Solubility of 7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one; dihydrochloride

The solubility characteristics of the compound 7-chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one; dihydrochloride can be quite interesting. This compound typically exhibits solubility in warm water due to its ionic dihydrochloride form, which enhances its interaction with polar solvents.

Key aspects of solubility:

  • Polar Solvents: The ionic nature of the dihydrochloride facilitates good solubility in polar solvents like water.
  • Temperature Effects: Like many organic compounds, solubility may increase with temperature; hence, heating the solvent can improve dissolution.
  • pH Dependency: The solubility can also be influenced by the pH of the solution, with more acidic environments potentially enhancing solubility due to increased ionization.

However, it’s crucial to note that while this compound may dissolve readily in certain conditions, its overall solubility profile should be evaluated through empirical testing for specific applications. This helps ensure effective use in pharmaceuticals or research, where solubility can significantly influence bioavailability and activity.

Interesting facts

Interesting Facts about 7-Chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one Dihydrochloride

7-Chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one dihydrochloride is a compound that falls within the class of benzodiazepines, which are widely recognized for their pharmacological properties. Here are some intriguing points about this compound:

  • Pharmacological Applications: Benzodiazepines are known for their use as anxiolytics, sedatives, and muscle relaxants. This compound may possess similar properties and serve as a candidate for therapeutic applications in treating anxiety disorders.
  • Structural Characteristics: The unique structure of this compound, featuring a chlorine atom and a dimethylamino group, contributes to its biological activity and interactions with neurotransmitter systems in the brain.
  • Mechanism of Action: Benzodiazepines generally work by enhancing the effects of the neurotransmitter GABA (gamma-aminobutyric acid), leading to increased neuronal inhibition. This mechanism may provide insight into treatment strategies for conditions related to heightened neuronal activity.
  • Research Potential: Due to its complex structure, this compound can be a subject of ongoing research to explore modifications that could enhance its efficacy and reduce potential side effects.
  • Comparative Studies: Scientists often compare different benzodiazepines, and this compound can be evaluated alongside others to determine its relative potency and safety profiles.

As a compound in the realm of medicinal chemistry, 7-Chloro-1-[2-(dimethylamino)-1-methyl-ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one dihydrochloride exemplifies the fascinating relationship between chemical structure and biological function. The exploration of such compounds not only deepens our understanding of therapeutic agents but also opens pathways to innovation in pharmaceutical development.

Synonyms
1242-71-3
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(2-(dimethylamino)-1-methylethyl)-5-phenyl-, dihydrochloride
DTXSID60924753
7-Chloro-1-[1-(dimethylamino)propan-2-yl]-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one--hydrogen chloride (1/2)