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Diazepam

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Identification
Molecular formula
C16H13ClN2O2
CAS number
439-14-5
IUPAC name
7-chloro-1-(2-morpholinoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is found in a solid state. It is usually stored as tablets or an injectable solution.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.00
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.00
General information
Molecular weight
284.75g/mol
Molar mass
284.7450g/mol
Density
1.3000g/cm3
Appearence

Diazepam is a crystalline compound with colors ranging from white to faintly yellow. It is typically found as a powder, which is odorless and tasteless.

Comment on solubility

Solubility of 7-chloro-1-(2-morpholinoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-1-(2-morpholinoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one can be quite complex due to its molecular structure, which affects its interaction with solvents. Generally, the solubility of this compound can be characterized by the following points:

  • Polarity: The presence of the morpholino group may contribute to increased polarity, enhancing solubility in polar solvents such as water.
  • Hydrophobic Character: The phenyl group incorporated in its structure introduces hydrophobic characteristics that may limit its solubility in purely aqueous solutions.
  • pH Dependency: The solubility may vary with pH, especially if the compound can ionize; this might lead to better solubility in acidic or basic environments compared to neutral pH.
  • Temperature Influence: As is the case with many organic compounds, increasing temperature generally enhances solubility, making this an important consideration in practical applications.

It is essential to consider these factors when determining the solubility profile of 7-chloro-1-(2-morpholinoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one. Understanding its solubility can aid significantly in pharmaceutical formulations and various chemical analyses.

Interesting facts

Interesting Facts about 7-Chloro-1-(2-morpholinoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one

The compound 7-chloro-1-(2-morpholinoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one is a fascinating member of the benzodiazepine family, known for its contributions to medicinal chemistry. This compound is often regarded for its pharmacological properties, particularly in the realm of anxiolytic and sedative effects.

Key Characteristics

  • Structure: The incorporation of a chloro group and a morpholinoethyl substituent contributes to the unique properties and activity of this compound.
  • Medical Relevance: As a benzodiazepine derivative, it's studied for its potential use in treating anxiety disorders and as a muscle relaxant.
  • Mechanism of Action: Like other benzodiazepines, it is thought to work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, leading to increased inhibitory neurotransmission.

Furthermore, research indicates that compounds such as this one may have fewer side effects compared to traditional benzodiazepines, making them a subject of interest in developing safer medication options.

Research Insights

  • Ongoing Studies: Scientists continue to study its efficacy and safety profile, drawing attention to potential improvements in drug delivery systems.
  • Comparative Analysis: It is often compared with other benzodiazepines to evaluate differences in therapeutic index and side effects.

In summary, 7-chloro-1-(2-morpholinoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one exemplifies the intricate relationship between chemical structure and biological activity, highlighting the significance of subtle modifications in medicinal chemistry. This compound not only showcases the complexity of benzodiazepine derivatives but also represents a promising avenue for future pharmacological developments.