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Diazepam

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Identification
Molecular formula
C16H13ClFN2O
CAS number
439-14-5
IUPAC name
7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is typically a solid in the form of a crystalline powder. When formulated into tablets, it retains a solid state, while in injectable solutions, it is dissolved in a suitable solvent and appears as a liquid.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.00
Boiling point (Celsius)
386.87
Boiling point (Kelvin)
660.00
General information
Molecular weight
284.75g/mol
Molar mass
284.1960g/mol
Density
1.3000g/cm3
Appearence

Diazepam appears as a white to light yellow crystalline powder. It is odorless and has a slightly bitter taste. The powder is usually available in tablet form or as an injectable solution for medical use.

Comment on solubility

Solubility of 7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one, a complex organic compound, can be influenced by various factors, including its molecular structure and polarity. There are several important considerations regarding its solubility:

  • Polar vs. Nonpolar: Due to the presence of both polar and nonpolar functional groups, this compound may exhibit variable solubility in different solvents.
  • Solvent Choice: It is likely to be more soluble in polar organic solvents such as ethanol or methanol than in nonpolar solvents like hexane.
  • Piperazine Ring Influence: The piperazine moiety can enhance solubility in aqueous environments due to its ability to form hydrogen bonds.
  • Functional Groups: The ethoxy group and the fluorophenyl moiety could also play a role in enhancing solubility by introducing additional polar characteristics.

In summary, the solubility of this compound can be described as moderate to good in polar solvents, but it could be limited in nonpolar solutions. This dual nature highlights the importance of solvent selection when working with such complex chemical structures.

Interesting facts

Interesting Facts about 7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine class, which is renowned for its influence in the realm of pharmacology, particularly owing to its effects on the central nervous system. Here are some intriguing aspects:

  • Drug Development: The design of benzodiazepines, including this compound, often aims to enhance anxiolytic (anti-anxiety) properties while minimizing side effects. Modifications in the side chains have led to variations in efficacy and safety profiles.
  • Piperazine Link: The incorporation of a piperazine ring in this compound contributes to its pharmacological activity. Piperazines are known to interact effectively with neurotransmitter receptors, which may influence mood and anxiety levels.
  • Fluorinated Analog: The presence of a fluorine atom in the phenyl group increases the compound's potency and bioavailability. Fluorination can significantly affect how a compound behaves in biological systems, potentially enhancing its therapeutic effects.
  • Structure-Activity Relationship (SAR): Understanding the SAR of this compound can help chemists anticipate how structural changes could alter its pharmacological profile, leading to more selective and effective formulations.
  • Potential Uses: Compounds like this one are often investigated for their potential not only as anxiolytics but also for other therapeutic applications such as anticonvulsants or muscle relaxants.

Overall, 7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one exemplifies the complexity and creativity involved in medicinal chemistry. As researchers continue to explore its properties, they may unlock new avenues for treating anxiety and other related disorders.