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Diazepam

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Identification
Molecular formula
C16H13ClN2O
CAS number
439-14-5
IUPAC name
7-chloro-1-[3-(4-methylpiperazin-1-yl)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
State
State

Diazepam is a solid at room temperature.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
386.00
Boiling point (Kelvin)
659.15
General information
Molecular weight
284.74g/mol
Molar mass
284.7460g/mol
Density
1.3040g/cm3
Appearence

Diazepam is a colorless to light yellow crystalline compound. It is soluble in water and has a characteristic benzodiazepine odor.

Comment on solubility

Solubility of 7-chloro-1-[3-(4-methylpiperazin-1-yl)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-1-[3-(4-methylpiperazin-1-yl)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one can be influenced by various factors due to its complex structure. Here are a few key points to consider:

  • Solvent Dependence: This compound may exhibit different solubilities in various solvents, generally being more soluble in organic solvents than in aqueous environments.
  • Temperature Effects: Increasing temperature typically enhances solubility for many organic compounds, making it crucial to conduct experiments at controlled temperatures.
  • pH Sensitivity: The solubility could also be pH-dependent, particularly if the compound has ionizable groups. Adjusting the pH of the solution can significantly impact how well the compound dissolves.
  • Interaction with Other Molecules: The presence of co-solvents or solubilizing agents may also increase the solubility of this compound by forming favorable interactions.

In summary, while 7-chloro-1-[3-(4-methylpiperazin-1-yl)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one has specific solubility traits, a comprehensive study in various solvent systems, temperatures, and pH levels is essential to fully understand its behavior in solution. As such, laboratory testing is recommended for precise solubility data.

Interesting facts

Interesting Facts About 7-Chloro-1-[3-(4-methylpiperazin-1-yl)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine family, a class of medications known for their psychoactive properties. Benzodiazepines are widely used for their anxiolytic, sedative, muscle relaxant, and anticonvulsant effects.

Here are some key points of interest regarding this specific compound:

  • Mechanism of Action: It exerts its effects by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA) at GABAA receptors.
  • Structural Diversity: The presence of the 4-methylpiperazin-1-yl moiety provides structural diversity, which can influence the compound's potency and selectivity for various receptor subtypes.
  • Potential Applications: Similar compounds have been investigated for their potential use in treating anxiety disorders, insomnia, and as muscle relaxants.
  • Caution: Long-term use of benzodiazepines can lead to dependency and tolerance, making it vital for users to follow medical guidance.

Furthermore, the inclusion of a chloro group at the seventh position and a phenyl group at the fifth position contributes not just to the compound's overall **chemical stability**, but also offers interesting potential for medicinal chemistry modifications. Chemists often explore these modifications for developing new therapeutic drugs with fewer side effects and enhanced efficacy.

As with any benzodiazepine derivative, research is ongoing to better understand its pharmacological properties and potential side effects. The intricate balance between therapeutic benefits and risks continues to make compounds like this a fascinating subject for study in both medicinal chemistry and pharmacology.

Synonyms
3332-91-0
7-Chloro-1,3-dihydro-1-[3-(4-methyl-1-piperazinyl)propyl]-5-phenyl-2H-1,4-benzodiazepin-2-one
DTXSID301119203