Skip to main content

Diazepam

ADVERTISEMENT
Identification
Molecular formula
C16H13ClFN2O
CAS number
439-14-5
IUPAC name
7-chloro-1-[3-(diethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is a solid compound.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
284.74g/mol
Molar mass
284.7430g/mol
Density
1.3060g/cm3
Appearence

Diazepam appears as a white or almost white crystalline powder. This compound is practically odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 7-chloro-1-[3-(diethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-1-[3-(diethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one can be influenced by various factors due to its complex structure. Typically, the solubility characteristics are as follows:

  • Polarity: The presence of diethylamino groups may enhance solubility in polar solvents.
  • Hydrogen Bonding: Potential interactions with water molecules can further modify its solubility profile.
  • Temperature Dependency: Higher temperatures may improve solubility, a common trend noted in organic compounds.
  • pH Sensitivity: The solubility can be pH-dependent, particularly for compounds with functional groups that can ionize.

As a result, while some benzodiazepines are known for relatively good solubility in organic solvents but limited solubility in water, this particular compound's solubility must be empirically determined to ensure accurate predictions. In summary:

  • Investigate aqueous and organic solvent behaviors
  • Consider environmental factors during experiments

Understanding the solubility of this compound is crucial for applications in pharmaceuticals, where the bioavailability often hinges on these properties.

Interesting facts

Exploring the Fascinating World of 7-chloro-1-[3-(diethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine class, which is known for its wide-ranging effects, particularly in the realm of pharmacology.

Key Characteristics:

  • Class of Compounds: Benzodiazepines are primarily used for their sedative, anxiolytic, muscle relaxant, and anticonvulsant properties.
  • Structure: The unique combination of a chlorine atom and a fluorophenyl group contributes to its distinct chemical behavior.
  • Modifications: The presence of a diethylamino side group enhances its pharmacological effects, influencing its interaction with various receptors in the brain.

Applications:

The applications of this compound extend beyond mere sedation. It may play a crucial role in:

  • **Anxiety Management**: Provides relief from anxiety disorders.
  • **Sleep Disorders**: Supplementing treatments for insomnia.
  • **Anticonvulsant**: Used in the management of seizures.

Research Significance:

Research on compounds like this one is vital for several reasons:

  • Mechanism Understanding: Analyzing how this compound interacts with GABAA receptors aids in our understanding of neurotransmitter systems.
  • Drug Development: Insights gleaned from studying its effects could lead to the development of new medications with fewer side effects.

As a result, compounds like 7-chloro-1-[3-(diethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one serve as a fascinating intersection between chemistry and medicine, underscoring the importance of chemical diversity in therapeutic development.