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Diazepam

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Identification
Molecular formula
C16H13ClN2O
CAS number
439-14-5
IUPAC name
7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
State
State
At room temperature, diazepam exists as a solid.
Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
284.71g/mol
Molar mass
284.7050g/mol
Density
1.3060g/cm3
Appearence

Diazepam appears as a colorless to light yellow crystalline compound. It is practically insoluble in water, slightly soluble in alcohol, and freely soluble in chloroform. It is usually available in the form of tablets and solutions for oral and injectable use.

Comment on solubility

Solubility of 7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one is an important characteristic that defines its behavior in various environments. This compound, like many benzodiazepines, displays unique solubility properties due to its molecular structure.

Key points regarding the solubility of this compound include:

  • Solvent Compatibility: The compound is generally more soluble in organic solvents compared to water, indicating that polar solvents may not effectively dissolve it.
  • pH Dependency: The solubility may vary with changes in pH, where it might become more soluble in slightly acidic to neutral conditions.
  • Temperature Effects: Increasing temperature often enhances solubility in organic solvents, which can be critical for applications such as drug formulation.

As stated, “solubility is the key to chemical interactions,” and for this compound, ensuring appropriate solvents and conditions is crucial for maximizing its efficacy in various applications. In pharmacology, understanding the solubility factors can profoundly affect the bioavailability and therapeutic effects of benzodiazepine derivatives.

In summary, navigating the solubility of this benzodiazepine requires a comprehensive understanding of its properties and interactions with different solvents.

Interesting facts

Interesting Facts about 7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one

This compound is known for its unique structure and potential applications in the field of pharmacology. As a member of the benzodiazepine family, it possesses properties that are significantly valuable in medical research and therapeutic practices.

Key Points

  • Classical Pharmacology: This compound interacts with the GABAA receptor, enhancing the inhibitory effects of neurotransmitters, which can lead to anxiolytic, sedative, and muscle relaxant effects.
  • Structural Diversity: The inclusion of a diethylamino group in its structure allows for distinctive pharmacokinetic profiles, one that is being explored for its potential to improve efficacy and reduce side effects.
  • Potential Uses: Being studied for various therapeutic applications, including anxiety disorders, insomnia, and other conditions requiring central nervous system modulation.
  • Synthetic Pathways: The synthesis of this compound involves advanced organic chemistry techniques, allowing chemists to dissect and optimize synthesis routes for better yields and purities.

In the realm of medicinal chemistry, benzodiazepines have long been a focal point due to their effectiveness and widespread use. As scholars delve deeper into this compound's unique properties, it sparks the excitement of potential novel medicaments for patients suffering from various ailments. As the world of pharmaceuticals continues to evolve, compounds like this remind us that structural subtlety can lead to significant therapeutic benefits.

Moreover, the exploration of such complex organic compounds not only enhances our understanding of their biological interactions but also offers students and chemists a glimpse into the rich tapestry of chemical innovation that defines modern science.