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Diazepam dihydrochloride

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Identification
Molecular formula
C16H13ClN2O·2HCl
CAS number
439-14-5
IUPAC name
7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one;dihydrochloride
State
State
At room temperature, diazepam dihydrochloride exists in a solid state. It is often stored in powder form for laboratory and medicinal use.
Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
525.00
Boiling point (Kelvin)
798.15
General information
Molecular weight
354.78g/mol
Molar mass
354.7800g/mol
Density
1.3060g/cm3
Appearence

Diazepam dihydrochloride is typically found as a white to off-white crystalline powder. It may also appear as colorless to light yellow crystals, depending on its purity and form.

Comment on solubility

Solubility of 7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one; dihydrochloride

The solubility of 7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one; dihydrochloride can be summarized as follows:

  • Solvent Dependence: This compound is known to be soluble in water, a trait attributed to the dihydrochloride form which ionizes to enhance solubility in polar solvents.
  • pH Influence: The solubility may vary with changes in pH; typically, higher solubility occurs in acidic conditions due to protonation of the nitrogen atoms in the diethylamino groups.
  • Comparison to Non-Salt Form: The free base form of this compound may exhibit markedly lower solubility in water compared to its hydrochloride salt, proving the effectiveness of salt formation in increasing solubility.
  • Applications in Formulation: Due to its solubility profile, this compound can be effectively utilized in various pharmaceutical formulations, ensuring bioavailability and therapeutic efficacy.

In summary, the solubility characteristics of this compound are influenced by ionic interactions and environmental conditions, making it a versatile ingredient for medicinal applications.

Interesting facts

Interesting Facts about 7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one; dihydrochloride

This compound is a member of the benzodiazepine family, a class of drugs that are widely recognized for their pharmacological properties, particularly in the treatment of anxiety, insomnia, and seizures. Here are some fascinating insights about this compound:

  • Medical Applications: Benzodiazepines like this one are commonly prescribed for their sedative and anxiolytic effects. They work by enhancing the effect of a neurotransmitter known as gamma-aminobutyric acid (GABA), which helps to calm the nervous system.
  • Structure and Functional Groups: The structural features of this compound, including the chloro and diethylamino groups, contribute significantly to its biological activity and pharmacokinetics. This specific arrangement can influence how the compound interacts with various receptors in the brain.
  • Research Significance: Compounds of this nature are of great interest in medicinal chemistry. Researchers often study their structure-activity relationships to develop new and more effective medications for psychiatric disorders.
  • Striking Balance: While benzodiazepines are effective, they also come with risks of dependence and withdrawal symptoms. Thus, understanding the precise actions of compounds like this one is crucial for developing safer alternatives.
  • Legacy of Innovation: Newer derivatives derived from classic benzodiazepine structures continue to emerge, expanding the arsenal of therapeutic agents available to clinicians and researchers alike.

In summary, 7-chloro-1-[3-(diethylamino)propyl]-5-phenyl-3H-1,4-benzodiazepin-2-one; dihydrochloride represents a pivotal area of study in pharmacology and medicinal chemistry, bridging the gap between structural innovation and therapeutic efficacy. Its continued exploration may pave the way towards more innovative treatments for debilitating conditions.

Synonyms
1248-22-2
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(3-(diethylamino)propyl)-5-phenyl-, dihydrochloride
DTXSID50154486
7-Chloro-1-(3-(diethylamino)propyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 2HCl
DTXCID9076977