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Clonazepam

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Identification
Molecular formula
C15H10ClFN2O
CAS number
1622-61-3
IUPAC name
7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, clonazepam is in a solid state. It is typically found in the form of tablets, often used in the pharmaceutical field as an anti-seizure or anti-anxiety medication.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
315.72g/mol
Molar mass
315.7150g/mol
Density
1.3000g/cm3
Appearence

Clonazepam appears as a white to light yellow crystalline powder. It is sparsely soluble in water, which means it does not dissolve entirely in water, but is slightly more soluble in methanol and ethanol.

Comment on solubility

Solubility Overview

The compound 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one exhibits specific solubility characteristics that are influenced by its molecular structure and the presence of functional groups.

Key Factors Affecting Solubility

  • Polarity: The presence of polar functional groups, such as the dimethylamino group, can enhance solubility in polar solvents. However, the aromatic rings may introduce hydrophobic portions that can hinder solubility in water.
  • pH Dependence: This compound may show variable solubility in aqueous solutions depending on the pH, as it may exist in different ionic forms.
  • Temperature Effects: Typically, an increase in temperature can lead to improved solubility for many organic compounds, including this one.

General Observations

It is essential to consider the following when evaluating the solubility:

  • The compound might be soluble in organic solvents such as ethanol and methanol.
  • Water solubility is likely limited due to the hydrophobic nature of the benzodiazepine core.
  • Interactions with other solvents and solubility modulators could provide insights into its behavior in various environments.

In conclusion, the solubility of 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one is complex and subject to numerous factors, thereby requiring careful consideration in practical applications.

Interesting facts

Interesting Facts about 7-Chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one

This compound is a member of the benzodiazepine class, which is well-known for its psychoactive properties. Benzodiazepines are often utilized in medicine for their ability to induce sedation, relieve anxiety, and facilitate muscle relaxation. Here are some intriguing aspects of this specific compound:

  • Structure and Function: The benzodiazepine core structure is known for its ability to modulate the GABAA receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain. This mechanism is fundamental to its anxiolytic and hypnotic effects.
  • Substituents: The presence of chlorine and fluorine atoms in its structure greatly influences the compound's pharmacological profile. These halogens can enhance lipophilicity, potentially improving the ability of the compound to cross the blood-brain barrier.
  • Dimethylamino Group: The dimethylamino side chain is often associated with increased potency. It can modulate the interaction of the compound with neurotransmitter receptors, making the compound an interesting candidate for further research in neuropharmacology.
  • Potential Therapeutic Uses: Due to its unique characteristics, this compound may offer potential in treating anxiety disorders, panic disorders, and insomnia, similar to other benzodiazepines. The distinct substituents may lead to variations in efficacy and side effect profiles.

As a pharmaceutical scientist or chemist, studying such compounds can reveal insights into structure-activity relationships (SAR) that are essential for drug development. The ongoing exploration of benzodiazepines continues to be vital in understanding their effects and enhancing their therapeutic uses.

In conclusion, the fascinating world of benzodiazepines, embodied by compounds like 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one, showcases the intricate balance between molecular structure and pharmacological action.

Synonyms
CHEMBL86553