Interesting facts
Interesting Facts about 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one; dihydrochloride
This compound, belonging to the benzodiazepine class, holds significant interest in medicinal chemistry due to its potential therapeutic applications. Here are some intriguing aspects to note:
- Pharmacological Relevance: Benzodiazepines are primarily known for their effects on the central nervous system, showcasing properties like anxiolytic, sedative, and muscle relaxant effects. This particular compound may exhibit similar advantages, potentially aiding in the treatment of anxiety and sleep disorders.
- Structural Highlights: The presence of the chlorine atom at the 7-position and the dimethylamino propyl group significantly influence the compound's activity and selectivity, showcasing the complexity of drug design where even minor changes can lead to drastic shifts in potency.
- Fluorine's Impact: The inclusion of a fluorophenyl group is noteworthy. Fluorine is often integrated into drug molecules as it can enhance metabolic stability, bioavailability, and the pharmacokinetic profile of the compound, making it an essential atom in modern medicinal chemistry.
- Synthesis Insights: The synthesis of such benzodiazepine derivatives involves multiple steps, typically including the introduction of halogens and amines under carefully controlled conditions, reflective of advanced organic chemistry techniques.
- Research Potential: Ongoing research is likely to investigate the drug's efficacy and optimization, which might include structure-activity relationship (SAR) studies, aiming to refine its therapeutic index and minimize side effects.
Overall, this compound exemplifies the intricate balance of structure and function in drug design, reminding scientists and students alike of the pivotal role that chemistry plays in developing effective pharmaceutical therapies.
Synonyms
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(3-(dimethylamino)propyl)-5-(o-fluorophenyl)-, dihydrochloride
4130-72-7
DTXSID90194285
DTXCID00116776
Solubility of 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one; dihydrochloride
The solubility of 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one; dihydrochloride can be characterized based on its unique chemical structure. This compound is known to exhibit variable solubility in different solvents, which can be summarized as follows:
It is critical to consider physicochemical properties such as pKa values and melting points when evaluating solubility, as these can greatly influence the compound's behavior in different environments. The solubility profile is crucial for applications in pharmacology and formulation development, making it essential for researchers to tailor dissolution conditions for optimal usage.
As always, understanding the solubility behavior of such compounds can lead to better designs for dosage forms and increase their therapeutic efficacy.