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Clonazepam

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Identification
Molecular formula
C15H10ClFN2O
CAS number
1622-61-3
IUPAC name
7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one
State
State

Clonazepam is typically found in a solid state at room temperature. In clinical settings, it is often provided in the form of tablets or orally disintegrating tablets.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.15
Boiling point (Celsius)
434.00
Boiling point (Kelvin)
707.15
General information
Molecular weight
315.72g/mol
Molar mass
315.7180g/mol
Density
1.5490g/cm3
Appearence

Clonazepam typically appears as an off-white to light yellow powder or crystal. It may also come as a colorless or light yellow solution when in dissolved form. The compound is often supplied as scored tablets for medical use.

Comment on solubility

Solubility of 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one can be characterized by several factors:

  • Polarity: The presence of polar functional groups such as the dimethylamino component may enhance solubility in polar solvents like water.
  • Hydrophobic Character: The fluorophenyl and benzodiazepine rings increase hydrophobic interactions, potentially making the compound less soluble in aqueous solutions.
  • pH Sensitivity: The solubility may also vary with pH due to ionization of the amine group, which could either hinder or facilitate solubility depending on the environment.
  • Temperature Dependence: Generally, an increase in temperature can lead to increased solubility for many organic compounds, including this benzodiazepine derivative.

In summary, while this compound may exhibit moderate solubility in water, it is more likely to be soluble in organic solvents. Understanding its solubility can provide insights into its chemical behavior and potential applications in various fields.

Interesting facts

Interesting Facts about 7-Chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-4,5-dihydro-3H-1,4-benzodiazepin-2-one

This compound is a fascinating member of the benzodiazepine class, which is widely known for its psychoactive properties. Benzodiazepines play a crucial role in medicinal chemistry, particularly in the treatment of anxiety, insomnia, and other central nervous system disorders.

Chemical Structure and Functionality

The unique structure of this compound, featuring both chlorine and fluorine substituents, contributes to its distinctive chemical behavior and biological activity. Here are some notable aspects:

  • Haloalkyl Groups: The presence of both a chlorine atom (7-chloro) and a fluorobenzene moiety introduces unique electronic effects that stabilizes the compound's receptor binding.
  • Dimethylamino Group: The dimethylamino propyl side chain (3-(dimethylamino)propyl) enhances its lipid solubility, facilitating better absorption in biological systems.

Pharmacological Implications

This compound exhibits a range of pharmacological activities, primarily due to its interaction with the GABAA receptor:

  • Anxiolytic Effects: As a modulator of GABAA receptors, it is known to produce calming effects, making it effective for anxiety relief.
  • Hypnotic Properties: It has sedative qualities that can induce sleep, being useful in the management of sleep disorders.

Research and Development

Given its complex structure, this compound is a subject of continuous research, aimed at improving its therapeutic profile. Scientists are particularly interested in:

  • Developing derivatives with reduced side effects but enhanced potency.
  • Exploring its potential for treating various neurological conditions beyond anxiety and insomnia.

As we delve deeper into the chemistry of such compounds, the balance between efficacy and safety remains a pivotal area of study, emphasizing the importance of structure-activity relationships in drug design.