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Diltiazem

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Identification
Molecular formula
C22H26ClN3O4S
CAS number
42399-41-7
IUPAC name
7-chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one
State
State

At room temperature, Diltiazem hydrochloride is in a solid crystalline state.

Melting point (Celsius)
212.00
Melting point (Kelvin)
485.00
Boiling point (Celsius)
532.50
Boiling point (Kelvin)
805.70
General information
Molecular weight
414.96g/mol
Molar mass
414.9620g/mol
Density
1.3000g/cm3
Appearence

The compound is a white to off-white crystalline powder. It is often observed as an odorless substance.

Comment on solubility

Solubility of 7-chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one

The solubility of 7-chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one can be quite significant when considering its chemical structure and functional groups. Several factors influence the solubility behavior of this compound:

  • Polarity: The presence of both a benzothiazepine core and a dimethylamino group contributes to its polar characteristics, allowing for potential interactions with polar solvents.
  • Hydrogen Bonding: The functional groups, particularly the amine, may facilitate hydrogen bonding, enhancing solubility in polar solvents like water.
  • Solvent Effects: It may exhibit better solubility in organic solvents such as ethanol or DMSO due to the non-polar regions within its structure.

In general, the solubility of this compound may also be affected by environmental factors:

  • Temperature: Higher temperatures typically increase solubility in both organic and aqueous environments.
  • pH Levels: The ionization state of the dimethylamino group can change with pH, significantly altering solubility.

In summary: 7-chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one demonstrates a complex solubility profile, largely dictated by its molecular structure and the nature of the solvent used. Understanding these factors is crucial for effective formulation and application in various chemical processes.

Interesting facts

Interesting Facts about 7-Chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one

7-Chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one is a fascinating compound that belongs to the class of benzothiazepines, which are structurally unique and biologically significant. Here are some intriguing aspects of this compound:

  • Pharmacological Relevance: This compound has been studied for its potential therapeutic applications. Benzothiazepines are often explored for their activity in treating conditions such as hypertension and anxiety disorders due to their ability to interact with calcium channels.
  • Structure-Activity Relationship: The incorporation of a chloro group, particularly at the 7-position, enhances the pharmacological profile of the compound by altering its lipophilicity, which can affect how the drug interacts with biological targets.
  • Dimethylamino Group: The presence of a dimethylamino group is notable as it can influence the compound's overall basicity and solubility. This functional group can also play a key role in the compound's ability to cross biological membranes, a crucial factor for drug efficacy.
  • Potential for Novel Applications: Researchers are continuously exploring this class of compounds for new therapeutic properties, making them of great interest in medicinal chemistry.
  • Emerging Research: Recent studies may focus on diverse applications ranging from neuroprotective effects to cardiovascular health, underscoring the compound's versatility.

Overall, 7-Chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one showcases how structural modifications can lead to significant changes in biological activity and therapeutic potential, making it a valuable subject of study within the field of chemistry and pharmacology.

Synonyms
7-chloro-1-[3-(dimethylamino)propyl]-5H-4,1-benzothiazepin-2-one
13540-16-4
DTXSID20274802