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Chlordiazepine

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Identification
Molecular formula
C16H13ClN2S
CAS number
6948-21-2
IUPAC name
7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione
State
State

At room temperature, Chlordiazepine is typically found in a solid state.

Melting point (Celsius)
174.50
Melting point (Kelvin)
447.70
Boiling point (Celsius)
324.50
Boiling point (Kelvin)
597.70
General information
Molecular weight
316.81g/mol
Molar mass
316.8110g/mol
Density
1.4000g/cm3
Appearence

Chlordiazepine typically appears as a solid crystalline powder with a pale yellow color. The compound may show some sheen under light, and it maintains a consistent texture across samples.

Comment on solubility

Solubility of 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione

The solubility of 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione is a topic of interest due to its implications in pharmaceutical applications. Here are some key points regarding its solubility:

  • Solvent Dependence: The solubility can vary significantly depending on the solvent. For instance, it demonstrates better solubility in organic solvents compared to aqueous environments.
  • pH Influence: The solubility may also be affected by the pH of the solution, where certain acidic or alkaline conditions can enhance or hinder dissolution.
  • Temperature Effects: Generally, an increase in temperature can lead to an increase in solubility—a phenomenon consistent with many organic compounds.
  • Complex Formation: There is potential for this compound to form complexes with other molecules, which can modify its effective solubility.

Overall, while the solubility of 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione might not be universally high, understanding the specific conditions and solvents can allow for advantageous use in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione

The fascinating world of benzodiazepines brings us to a unique compound, 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione. This compound belongs to a class of medications known for their psychoactive properties, primarily utilized to treat anxiety and insomnia. Here are some intriguing insights about this compound:

  • Core Component: The 1,4-benzodiazepine structure is pivotal, consisting of a fused benzene and diazepine ring, which is integral for the molecule's biological activity.
  • Substituents Matter: The positioning of the chloro (-Cl) and methyl (-CH₃) groups and the presence of the phenyl group significantly influence the compound's pharmacokinetics and pharmacodynamics.
  • Mechanism of Action: This compound, like other benzodiazepines, functions primarily by enhancing the effect of the neurotransmitter GABA (gamma-aminobutyric acid) at the GABAA receptor, leading to a calming effect on the nervous system.
  • Medical Importance: While not as commonly discussed in clinical practices, compounds like this may help in the development of new therapeutic agents for anxiety and related disorders.
  • Research Potential: The compound holds promise for further research due to its unique modifications, potentially leading to breakthroughs in understanding drug-receptor interactions.

As with many compounds in medicinal chemistry, the emphasis on structure-activity relationships (SAR) can open new avenues for the development of drugs with fewer side effects and greater efficacy. Exploring benzodiazepines continues to be a significant area of study, uncovering the complexities of our neural pathways.

In the words of a seasoned chemist, "Understanding the depths of chemical interactions paves the way for innovative therapeutic solutions." This statement perfectly encompasses the journey of studying compounds like 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione, showcasing the profound impact that chemistry can have on health and medicine.

Synonyms
Sulazepam
2898-13-7
W 3676
7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepine-2-thione
2H-1,4-BENZODIAZEPINE-2-THIONE, 7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-
NZ779Q5S0W
7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-thione
DTXSID1046267
7-Chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)-thione
W-3676
NCGC00160641-01
Sulazepamum
Sulazepam [USAN:INN]
Sulazepamum [INN-Latin]
BRN 0754372
UNII-NZ779Q5S0W
Sulazeparn
SULAZEPAM [INN]
Sulazepam (USAN/INN)
SULAZEPAM [USAN]
7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-thione
5-24-04-00355 (Beilstein Handbook Reference)
SCHEMBL636226
CHEMBL1891606
DTXCID9026267
MWGWTOPCKLQYEU-UHFFFAOYSA-N
Tox21_111948
7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1,4-benzodiazepine-2-thione
BDBM50452384
MFCD00868155
AKOS005067993
FC46885
CAS-2898-13-7
NS00123617
D05942
Q7636056
7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-thione #