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Clozapine

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Identification
Molecular formula
C18H19ClN4O
CAS number
5786-21-0
IUPAC name
7-chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one
State
State

At room temperature, Clozapine is in a solid state. It is typically encountered in the form of a crystalline powder when used in pharmaceutical formulations.

Melting point (Celsius)
183.50
Melting point (Kelvin)
456.70
Boiling point (Celsius)
441.20
Boiling point (Kelvin)
714.20
General information
Molecular weight
326.82g/mol
Molar mass
326.8270g/mol
Density
1.3005g/cm3
Appearence

Clozapine is a pale yellow to yellow, crystalline powder. It is sparingly soluble in water but soluble in various organic solvents.

Comment on solubility

Solubility of 7-chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one

The solubility of 7-chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one exhibits interesting characteristics depending on the solvent used. Here are several key points to consider:

  • Polar Solvents: The presence of the dimethylamino group generally promotes solubility in polar solvents, such as water and alcohols, due to hydrogen bonding and dipole-dipole interactions.
  • Non-Polar Solvents: This compound may exhibit lower solubility in non-polar solvents, such as hexane or chloroform, due to hydrophobic interactions prevailing in such environments.
  • pH Sensitivity: The solubility can also be influenced by pH, where ionization of the dimethylamino group can enhance solubility in acidic or basic conditions.
  • Temperature Effects: An increase in temperature often results in improved solubility for many organic compounds, making it a factor worth considering in practical applications.
  • Complex Formation: Interaction with other chemical species can lead to complex formation, potentially altering the solubility profile.

In conclusion, the solubility of 7-chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one is contingent upon various factors including solvent polarity, pH, and temperature, making it essential to consider these variables when predicting its behavior in different environments.

Interesting facts

Interesting Facts about 7-Chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one

7-Chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one is a remarkable compound that straddles the interface between chemistry and pharmacology. Here are some fascinating insights:

  • Versatile Therapeutics: This compound belongs to an intriguing class of compounds known for their potential in medicinal chemistry. It has drawn attention in drug development, particularly in the realm of anticancer agents.
  • Mechanistic Action: Researchers are investigating how compounds of this nature interact with biological pathways. Their ability to inhibit specific enzymes or receptors can mean a significant impact on cell signaling and proliferation.
  • Structural Features: The unique naphthyridine structure contributes to the compound's biological activity. Compounds with naphthyridine motifs are noted for their ability to fit into active sites of biomolecules, enhancing binding interactions.
  • Substituent Effects: The presence of a dimethylamino propyl group greatly influences the compound’s properties. It can enhance solubility and bioavailability, factors that are crucial in drug design.
  • Research Applications: This compound has garnered attention in ongoing research studies aimed at understanding its potential as a lead compound for the development of novel therapeutics. It serves as a scaffolding structure for creating analogs with varied biological effects.
  • Real-World Implications: The ongoing exploration into its properties and effects can lead to significant advancements in treatments for various diseases, particularly those that are currently hard to treat.

In conclusion, 7-Chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one represents a cutting-edge area of study where structural chemistry meets biological efficacy, making it a compelling subject for chemists and pharmacologists alike.

Synonyms
Benzonaphthyridone
28907-44-0
10-(3-Dimethylaminopropyl)-7-chlorobenzo(b)(1,8)naphthyrid-5-one
DTXSID20951540
7-Chloro-10-(3-(dimethylamino)propyl)benzo(b)(1,8)naphthyridin-5(10H)-one
7-Chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5(10H)-one
RefChem:118513
DTXCID301379657
7-chloro-10-[3-(dimethylamino)propyl]benzo[b][1,8]naphthyridin-5-one
IF C-45