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Tacrine

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Identification
Molecular formula
C13H14ClN
CAS number
321-64-2
IUPAC name
7-chloro-1,2,3,4-tetrahydroacridin-9-amine
State
State

Solid at room temperature.

Melting point (Celsius)
255.00
Melting point (Kelvin)
528.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
198.68g/mol
Molar mass
198.6800g/mol
Density
1.3000g/cm3
Appearence

Tacrine appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 7-chloro-1,2,3,4-tetrahydroacridin-9-amine

The solubility of 7-chloro-1,2,3,4-tetrahydroacridin-9-amine can vary based on several factors, which are essential to consider when assessing its practical applications. Here are some key points to note:

  • Solvent Types: This compound is likely to have better solubility in polar solvents due to its amine functional group. Common solvents include:
    • Water
    • Ethanol
    • Dimethyl sulfoxide (DMSO)
  • Temperature Impact: Generally, increased temperature can enhance the solubility of many organic compounds, including this one.
  • pH Consideration: The solubility may also be influenced by the pH of the solution, as the protonation of the amine group might improve its solubility in acidic conditions.
  • Crystallization Behavior: Due to its structural complexity, it may exhibit unique crystallization behaviors when involved in solution chemistry, which can affect its overall solubility.

In summary, the solubility of 7-chloro-1,2,3,4-tetrahydroacridin-9-amine is influenced by a multitude of factors, making it essential to conduct specific solubility tests under varied conditions to fully understand its behavior in different environments. As Marie Curie once said, “Nothing in life is to be feared, it is only to be understood.” This principle applies well in exploring solubility challenges in organic chemistry!

Interesting facts

Interesting Facts about 7-Chloro-1,2,3,4-tetrahydroacridin-9-amine

7-Chloro-1,2,3,4-tetrahydroacridin-9-amine, often referred to in scientific literature due to its potential applications in medicine, particularly in the field of neuroscience, exhibits several compelling characteristics:

  • Neuroprotective Properties: Research indicates that this compound may possess neuroprotective effects, making it a subject of interest for the treatment of neurodegenerative diseases.
  • Cholinesterase Inhibition: As an inhibitor of cholinesterase, it can influence acetylcholine levels, potentially enhancing cognitive function. This mechanism is particularly relevant in Alzheimer's research.
  • Synthetic Pathways: The synthetic routes to obtain this compound often involve multiple steps that highlight important reactions in organic chemistry, such as reduction and halogenation, making it a great example for students learning synthesis.
  • Pharmacological Studies: Ongoing pharmacological studies are exploring its efficacy and safety, positioning it as a promising candidate for drug development.
  • Structure-Activity Relationship: The unique structure of 7-chloro-1,2,3,4-tetrahydroacridin-9-amine allows researchers to investigate the structure-activity relationship (SAR), providing insights into how changes in its chemical structure affect biological activity.

In the words of prominent chemist John E. Walker, “Understanding the compound's intricate interactions with biological systems is pivotal for developing targeted therapies.” This emphasizes not only the significance of this compound in advanced research but also the innovative approaches taken by scientists to unravel its full potential.

In summary, 7-chloro-1,2,3,4-tetrahydroacridin-9-amine stands out as an intriguing compound, with its properties inspiring future research aimed at improving our understanding of neurodegenerative disorders.

Synonyms
6115-67-9
7-chloro-1,2,3,4-tetrahydroacridin-9-amine
9-Amino-7-chloro-1,2,3,4-tetrahydro-acridine
ACRIDINE, 1,2,3,4-TETRAHYDRO-9-AMINO-7-CHLORO-
BRN 0394541
2-chloro-5,6,7,8-tetrahydroacridin-9-amine
9-Amino-7-chloro-1,2,3,4-tetrahydroacridine
ZE32NYP4EA
CHEMBL62084
BDBM8986
DTXSID20210043
AKOS011482955
PD183091
CS-0102415
7-Chloro-1,2,3,4-tetrahydro-9-acridinamine
F79878
7-Chloranyl-1,2,3,4-tetrahydroacridin-9-amine