Skip to main content

Chlorothiazide

ADVERTISEMENT
Identification
Molecular formula
C7H6ClN3O4S
CAS number
58-94-6
IUPAC name
7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
State
State

At room temperature, chlorothiazide is in solid state. It is commonly stored under dry conditions in light-resistant containers to maintain its stability.

Melting point (Celsius)
355.00
Melting point (Kelvin)
628.15
Boiling point (Celsius)
880.00
Boiling point (Kelvin)
1 153.15
General information
Molecular weight
296.72g/mol
Molar mass
296.7150g/mol
Density
1.6947g/cm3
Appearence

Chlorothiazide appears as a white to practically white crystalline powder. It is often available in tablet form for medicinal use, characterized by its fine texture. This compound does not have any significant coloring or odor.

Comment on solubility

Solubility of 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide

The solubility of 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide (C7H6ClN3O4S) can vary depending on several factors, including temperature, pH, and the solvent used. Here are some key points to consider:

  • Polarity: The presence of a sulfonamide group (–SO2NH2) in the structure increases the compound's polarity, which may enhance its solubility in polar solvents such as water.
  • Solvent Effects: While it may exhibit reasonable solubility in organic solvents, its performance in aqueous environments might differ, primarily due to the competing hydrogen bonding and interactions of solute and solvent.
  • Temperature Influence: As a general rule, an increase in temperature tends to improve the solubility of solids in liquids, potentially making this compound more soluble at elevated temperatures.
  • pH Considerations: The solubility might also be influenced by the pH of the solution, particularly if the sulfonamide moiety exists in a protonated or deprotonated form, which can alter its interaction with solvents.

Overall, while the exact solubility parameters require experimental determination for precise values, the above factors suggest a nuanced solubility profile for this intriguing compound.

Interesting facts

Interesting Facts about 7-Chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide

7-Chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide is a fascinating compound with a variety of potential applications, particularly in medicinal chemistry. Here are some key highlights:

  • Structural Complexity: This compound features a quinazoline framework, which is a bicyclic structure that contains both a benzene and a pyrimidine ring. This unique structure contributes to its biological activity.
  • Pharmacological Properties: Compounds in the quinazoline family are known for their pharmacological properties, including anticancer, anti-inflammatory, and antimicrobial activities. Researchers are interested in exploring the therapeutic potential of this particular compound.
  • Sulfonamide Group: The inclusion of a sulfonamide group enhances solubility and bioactivity, making it a valuable component in drug design. This group is commonly found in various drug structures and plays a crucial role in targeting specific biological pathways.
  • Chlorine Substitution: The presence of a chlorine atom can significantly influence the compound's reactivity and biological interactions. Chlorine atoms can enhance the lipophilicity of compounds, potentially improving their ability to penetrate cell membranes.

Overall, 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide is more than just a chemical compound; it represents a realm of possibilities in drug discovery and development. Scientists are continually inspired by such compounds as they pave the way for new treatments and therapies. As the saying goes, “Chemistry is the art of conversion,” and this compound exemplifies that creativity in its design and potential applications.

Synonyms
QUINETHAZONE
73-49-4
Chinethazonum
Quinethazon
Hydromox
Quinethazonum
Aquamox
Idrokin
Chinetazone
Quinetazona
Chinetazone [DCIT]
Quinetazona [INN-Spanish]
Quinethazonum [INN-Latin]
CL 36010
7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
CCRIS 6098
QUINETHAZONE (1.5 G)
HSDB 3392
EINECS 200-801-7
7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide
NSC-759904
BRN 0818554
CHEBI:8717
7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
DTXSID9023548
UNII-455E0S048W
7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline
7-Chloro-2-ethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone
6-Quinazolinesulfonamide, 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-
455E0S048W
2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxochinazolin-6-sulfonamid
DTXCID703548
Quinethazone [USP:INN:BAN:JAN]
5-25-09-00214 (Beilstein Handbook Reference)
NSC 759904
HYDROMOX R COMPONENT QUINETHAZONE
2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxoquinazoline-6-sulfonamide
6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-7-chloro-2-ethyl-4-oxo-
Quinetazona (INN-Spanish)
Quinethazonum (INN-Latin)
QUINETHAZONE (MART.)
QUINETHAZONE [MART.]
Quinethazone (aquamox)
Chinethazone
Quinethazone (USP:INN:BAN:JAN)
Hydromox (TN)
Quinethazone (JAN/INN)
quinetazone
CAS-73-49-4
NCGC00016313-01
starbld0009648
Prestwick0_001050
Prestwick1_001050
Prestwick2_001050
Prestwick3_001050
QUINETHAZONE [MI]
QUINETHAZONE [INN]
QUINETHAZONE [JAN]
QUINETHAZONE [HSDB]
CHEMBL1532
QUINETHAZONE [VANDF]
BSPBio_000980
MLS002154126
QUINETHAZONE [WHO-DD]
SCHEMBL301310
SPBio_002910
BPBio1_001078
GTPL7289
BDBM25898
C03BA02
HMS1571A22
HMS2098A22
HMS2234O04
HMS3370M01
HMS3715A22
Pharmakon1600-01503877
QUINETHAZONE [ORANGE BOOK]
AAA07349
BCP07451
HY-B1364
Tox21_110366
AC8883
EX-A11114
MFCD00867329
NSC759904
ZINC00000686
AKOS040753678
Tox21_110366_1
CCG-213232
DB01325
NCGC00179351-03
DA-57307
SMR001233433
SY250224
QUINETHAZONE COMPONENT OF HYDROMOX R
AB00514022
CS-0013105
NS00037523
C07342
D00461
AB00514022_06
EN300-18568085
SR-01000841190
Q7272222
SR-01000841190-2
BRD-A59303141-001-03-9
BRD-A59303141-001-10-4
2-Ethyl-7-chloro-2,3-dihydro-4(1H)-quinazolone-6-sulfonamide
7-chloro-2-ethyl-4-hydroxy-1,2-dihydroquinazoline-6-sulfonamide
7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinzaolinesulfonamide
200-801-7