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Diazepam

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Identification
Molecular formula
C16H13ClN2O4
CAS number
439-14-5
IUPAC name
(7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl) 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate
State
State

At room temperature, diazepam is in a solid state. It is typically provided in tablet form, capsules, or a solution for rectal or intravenous use.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
246.00
Boiling point (Kelvin)
519.15
General information
Molecular weight
284.75g/mol
Molar mass
284.7500g/mol
Density
1.2000g/cm3
Appearence

Diazepam typically appears as a white to light yellow crystalline powder. It is practically odorless, which makes it suitable for various formulations without affecting the sensory properties.

Comment on solubility

Solubility Characteristics

The compound (7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl) 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate presents intriguing solubility behavior that is influenced by its complex structural features. Understanding its solubility is key to predicting its behavior in different environments.


Key Points on Solubility:

  • Polarity: The presence of various functional groups, such as chloro, oxo, and methoxy, contributes to the polarity of the molecule. This can affect its solubility in polar versus non-polar solvents.
  • Solvent Interaction: It's hypothesized that polar solvents like water may have limited solubility due to the hydrophobic phenyl and indole rings; however, organic solvents such as DMSO or ethanol might enhance its solubility.
  • Hydrogen Bonding: Functional groups capable of hydrogen bonding may increase solubility in specific solvents.
  • pH Dependence: The ionization of the compound may vary with pH, potentially altering its solubility in aqueous solutions. Understanding its pKa values could provide insights into its solubility profile at different pH levels.

Overall, the solubility of this compound is a multifaceted topic, and thorough investigation is crucial. As one might say, "Nature always finds a way," highlighting the adaptive strategies of compounds in various environments.

Interesting facts

Interesting Facts about (7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl) 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate

This fascinating compound is a member of the benzodiazepine family, known for their diverse pharmacological properties. Here are some captivating insights into this compound:

  • Structural Complexity: The compound possesses a unique structure that combines elements from both benzodiazepines and indoles, showcasing the versatility of organic chemistry in molecular design.
  • Potential Therapeutic Uses: Compounds like this one are often researched for their potential applications in the treatment of anxiety, insomnia, and other psychological disorders due to the tranquilizing effects associated with benzodiazepines.
  • Chlorine Substituents: The presence of chlorine atoms in its structure may influence the pharmacokinetics and biological activity of the compound, highlighting the importance of halogen substituents in drug design.
  • Research Interest: Chemical compounds with hybrid functionality, like this one, are of great interest in medicinal chemistry. They are often synthesized to explore new therapeutic avenues and understand structure-activity relationships.
  • Indole Component: The indole moiety is known for its natural occurrence in many biological systems and its significance in the development of pharmaceuticals, making this compound intriguing from a biochemical perspective.

As a chemistry student or scientist exploring this compound, consider the implications of its structure on its function and efficacy. The intricate dance of atoms in such complex compounds often leads to surprising discoveries in the realm of medicinal chemistry!

Synonyms
SAS 562
Estere dell'ossazepam con indometacina [Italian]
BRN 0737558
20231-05-4
Estere dell'ossazepam con indometacina
Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-, ester with 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
RefChem:349306
DTXSID60942336
(7-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate
7-Chloro-2-hydroxy-5-phenyl-3H-1,4-benzodiazepin-3-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate