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Clonazepam

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Identification
Molecular formula
C16H10ClN3O3
CAS number
1622-61-3
IUPAC name
7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid
State
State

At room temperature, clonazepam is in a solid state. It is stable and does not undergo any significant changes under standard conditions of temperature and pressure.

Melting point (Celsius)
239.50
Melting point (Kelvin)
512.65
Boiling point (Celsius)
435.30
Boiling point (Kelvin)
708.45
General information
Molecular weight
316.72g/mol
Molar mass
316.7150g/mol
Density
1.5000g/cm3
Appearence

Clonazepam is typically a white to light yellow crystalline powder. Being visually assessed, its crystals are often very fine or occur in a microcrystalline form. Due to its nature, it does not have a distinct or descriptive odor.

Comment on solubility

Solubility of 7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid

The solubility of 7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid (C16H10ClN3O3) can be influenced by various factors. This compound shows specific solubility patterns that can be summarized as follows:

  • Polarity: Due to the presence of both a carbonyl group and carboxylic acid moieties, the compound exhibits polar characteristics.
  • Solvent Compatibility: It is likely to be more soluble in polar solvents like water and methanol, while having reduced solubility in non-polar solvents like hexane.
  • pH Influence: The solubility is likely to increase in basic conditions due to deprotonation of the carboxylic acid group, enhancing its overall solubility.
  • Temperature Considerations: Increasing temperature generally enhances solubility for many organic compounds, making it potentially more soluble in warmer solutions.

In conclusion, while 7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid has relatively moderate solubility potential, the specific solvent and environmental conditions play crucial roles in its solubility behavior. Understanding these parameters is essential for effective application in chemical processes.

Interesting facts

Interesting Facts about 7-Chloro-2-Oxo-5-Phenyl-1,3-Dihydro-1,4-Benzodiazepine-3-Carboxylic Acid

The compound 7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid belongs to the class of benzodiazepines, which are widely recognized for their effects on the central nervous system. Here are some fascinating insights about this compound:

  • Pharmacological Interest: This compound exhibits potential therapeutic properties, making it a subject of interest in pharmaceutical research, particularly for its use in treating anxiety, insomnia, and seizures.
  • Structure and Stability: The benzodiazepine structure provides remarkable stability, and the presence of a chloro group enhances some aspects of its reactivity and biological activity.
  • Synthetic Pathways: The synthesis of this compound often involves multi-step reactions, which can include methods such as cyclization and functional group modifications, highlighting the creativity and complexity of synthetic organic chemistry.
  • Aromatic Character: The phenyl group in its structure contributes to the compound's aromatic properties, influencing its interaction with biological receptors and overall efficacy.
  • Research Applications: Research continues to explore derivatives of this benzodiazepine to enhance efficacy and reduce side effects, exemplifying how modifications can lead to improved medicinal properties.

As a chemistry student or scientist, one can appreciate not only the intricate structure but also the ongoing research and development surrounding compounds like this one. The fusion of chemistry and pharmacology in developing new treatments makes the study of such compounds both exciting and critical in advancing healthcare.

"In the world of benzodiazepines, subtle changes can lead to monumental impacts on health and disease management."

Synonyms
clorazepate
Clorazepic acid
Chlorazepate
Cchlorazepic acid
23887-31-2
149128-44-9
7-Chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid
HSDB 3041
7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid
EINECS 245-926-8
UNII-D51WO0G0L4
4306-CB FREE ACID
CHEBI:3761
D51WO0G0L4
ABBOTT-35616 FREE ACID
7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylic acid
Dipotassium clorazepate
1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-
7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid
Clorazepic acid [BAN]
DEA No. 2768
CLORAZEPIC ACID (MART.)
CLORAZEPIC ACID [MART.]
4306 CB
Tranxene&reg
1H-1,4-Benzodiazepine-3-carboxylicacid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, (-)-
(Chloromethyl)(dimethyl)(tridecyloxy)silane
CLORAZEPATE [VANDF]
CLORAZEPIC ACID [MI]
CLORAZEPIC ACID [HSDB]
GTPL7548
SCHEMBL1649064
CHEMBL1213252
SCHEMBL21244066
CLORAZEPIC ACID [WHO-DD]
DTXSID20863674
23887-31-2 (free acid)
DB00628
20432-69-3
NS00004505
C06921
Q418850
245-926-8